Inositol-1,3,4-trisphosphate 5/6-kinase

inositol-1,3,4-trisphosphate 5/6-kinase
Identifiers
EC number 2.7.1.159
CAS number 288307-53-9
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

inositol-1,3,4-trisphosphate 5/6-kinase (EC 2.7.1.159, Ins(1,3,4)P3 5/6-kinase, inositol trisphosphate 5/6-kinase) is an enzyme with systematic name ATP:1D-myo-inositol 1,3,4-trisphosphate 5-phosphotransferase.[1][2][3] This enzyme catalyses the following chemical reaction

(1) ATP + 1D-myo-inositol 1,3,4-trisphosphate ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
(2) ATP + 1D-myo-inositol 1,3,4-trisphosphate ADP + 1D-myo-inositol 1,3,4,6-tetrakisphosphate

In humans, this enzyme, along with EC 2.7.1.127 (inositol-trisphosphate 3-kinase), EC 2.7.1.140 (inositol-tetrakisphosphate 5-kinase) and EC 2.7.1.158 (inositol pentakisphosphate 2-kinase) is involved in the production of inositol hexakisphosphate (InsP6).

References

  1. ↑ Wilson, M.P.; Majerus, P.W. (1996). "Isolation of inositol 1,3,4-trisphosphate 5/6-kinase, cDNA cloning and expression of the recombinant enzyme". J. Biol. Chem. 271: 11904–11910. doi:10.1074/jbc.271.20.11904. PMID 8662638.
  2. ↑ Verbsky, J.W.; Chang, S.C.; Wilson, M.P.; Mochizuki, Y.; Majerus, P.W. (2005). "The pathway for the production of inositol hexakisphosphate in human cells". J. Biol. Chem. 280 (3): 1911–1920. doi:10.1074/jbc.M411528200. PMID 15531582.
  3. ↑ Miller, G.J.; Wilson, M.P.; Majerus, P.W.; Hurley, J.H. (2005). "Specificity determinants in inositol polyphosphate synthesis: crystal structure of inositol 1,3,4-trisphosphate 5/6-kinase". Mol. Cell. 18: 201–212. doi:10.1016/j.molcel.2005.03.016. PMID 15837423.
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