ITIH3

ITIH3
Identifiers
AliasesITIH3, H3P, ITI-HC3, SHAP, inter-alpha-trypsin inhibitor heavy chain 3
External IDsMGI: 96620 HomoloGene: 1669 GeneCards: ITIH3
Gene location (Human)
Chr.Chromosome 3 (human)[1]
Band3p21.1Start52,794,768 bp[1]
End52,809,009 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

3699

16426

Ensembl

ENSG00000162267

ENSMUSG00000006522

UniProt

Q06033

Q61704

RefSeq (mRNA)

NM_002217

NM_008407

RefSeq (protein)

NP_002208

NP_032433

Location (UCSC)Chr 3: 52.79 – 52.81 MbChr 14: 30.91 – 30.92 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Inter-alpha-trypsin inhibitor heavy chain H3 is a protein that in humans is encoded by the ITIH3 gene.[5][6][7]

See also

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000162267 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000006522 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Diarra-Mehrpour M, Bourguignon J, Sesboue R, Mattei MG, Passage E, Salier JP, Martin JP (Apr 1989). "Human plasma inter-alpha-trypsin inhibitor is encoded by four genes on three chromosomes". Eur J Biochem. 179 (1): 147–54. doi:10.1111/j.1432-1033.1989.tb14532.x. PMID 2465147.
  6. ↑ Jean L, Risler JL, Nagase T, Coulouarn C, Nomura N, Salier JP (May 1999). "The nuclear protein PH5P of the inter-alpha-inhibitor superfamily: a missing link between poly(ADP-ribose)polymerase and the inter-alpha-inhibitor family and a novel actor of DNA repair?". FEBS Lett. 446 (1): 6–8. doi:10.1016/S0014-5793(99)00173-8. PMID 10100603.
  7. ↑ "Entrez Gene: ITIH3 inter-alpha (globulin) inhibitor H3".

Further reading

  • Salier JP, Simon D, Rouet P, et al. (1992). "Homologous chromosomal locations of the four genes for inter-alpha-inhibitor and pre-alpha-inhibitor family in human and mouse: assignment of the ancestral gene for the lipocalin superfamily". Genomics. 14 (1): 83–8. doi:10.1016/S0888-7543(05)80287-3. PMID 1385302.
  • Enghild JJ, Salvesen G, Hefta SA, et al. (1991). "Chondroitin 4-sulfate covalently cross-links the chains of the human blood protein pre-alpha-inhibitor". J. Biol. Chem. 266 (2): 747–51. PMID 1898736.
  • Salier JP, Diarra-Mehrpour M, Sesboue R, et al. (1988). "Isolation and characterization of cDNAs encoding the heavy chain of human inter-alpha-trypsin inhibitor (I alpha TI): unambiguous evidence for multipolypeptide chain structure of I alpha TI". Proc. Natl. Acad. Sci. U.S.A. 84 (23): 8272–6. doi:10.1073/pnas.84.23.8272. PMC 299524. PMID 2446322.
  • Enghild JJ, Thøgersen IB, Pizzo SV, Salvesen G (1989). "Analysis of inter-alpha-trypsin inhibitor and a novel trypsin inhibitor, pre-alpha-trypsin inhibitor, from human plasma. Polypeptide chain stoichiometry and assembly by glycan". J. Biol. Chem. 264 (27): 15975–81. PMID 2476436.
  • Diarra-Mehrpour M, Bourguignon J, Sarafan N, et al. (1994). "Tandem orientation of the inter-alpha-trypsin inhibitor heavy chain H1 and H3 genes". Biochim. Biophys. Acta. 1219 (2): 551–4. doi:10.1016/0167-4781(94)90087-6. PMID 7522574.
  • Bourguignon J, Diarra-Mehrpour M, Thiberville L, et al. (1993). "Human pre-alpha-trypsin inhibitor-precursor heavy chain. cDNA and deduced amino-acid sequence". Eur. J. Biochem. 212 (3): 771–6. doi:10.1111/j.1432-1033.1993.tb17717.x. PMID 7681778.
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Blom AM, Thuveson M, Fries E (1998). "Intracellular coupling of bikunin and the heavy chain of rat pre-alpha-inhibitor in COS-1 cells". Biochem. J. 328 (1): 185–91. PMC 1218904. PMID 9359851.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Diarra-Mehrpour M, Sarafan N, Bourguignon J, et al. (1998). "Human inter-alpha-trypsin inhibitor heavy chain H3 gene. Genomic organization, promoter analysis, and gene linkage". J. Biol. Chem. 273 (41): 26809–19. doi:10.1074/jbc.273.41.26809. PMID 9756925.
  • Thuveson M, Fries E (1999). "Intracellular proteolytic processing of the heavy chain of rat pre-alpha-inhibitor. The COOH-terminal propeptide is required for coupling to bikunin". J. Biol. Chem. 274 (10): 6741–6. doi:10.1074/jbc.274.10.6741. PMID 10037773.
  • Bourguignon J, Borghi H, Sesboüé R, et al. (1999). "Immunohistochemical distribution of inter-alpha-trypsin inhibitor chains in normal and malignant human lung tissue". J. Histochem. Cytochem. 47 (12): 1625–32. doi:10.1177/002215549904701214. PMID 10567446.
  • Thuveson M, Fries E (2000). "The low pH in trans-Golgi triggers autocatalytic cleavage of pre-alpha -inhibitor heavy chain precursor". J. Biol. Chem. 275 (40): 30996–1000. doi:10.1074/jbc.M002399200. PMID 10893227.
  • Kato M, Seki N, Sugano S, et al. (2002). "Identification of sonic hedgehog-responsive genes using cDNA microarray". Biochem. Biophys. Res. Commun. 289 (2): 472–8. doi:10.1006/bbrc.2001.5976. PMID 11716497.
  • Paris S, Sesboüé R, Delpech B, et al. (2002). "Inhibition of tumor growth and metastatic spreading by overexpression of inter-alpha-trypsin inhibitor family chains". Int. J. Cancer. 97 (5): 615–20. doi:10.1002/ijc.10120. PMID 11807786.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.


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