Hydroxylamine dehydrogenase

Hydroxylamine dehydrogenase
Identifiers
EC number 1.7.2.6
CAS number 9075-43-8
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Hydroxylamine dehydrogenase (EC 1.7.2.6, HAO (ambiguous)) is an enzyme with systematic name hydroxylamine:ferricytochrome-c oxidoreductase.[1][2][3][4][5] This enzyme catalyses the following chemical reaction

(1) hydroxylamine + H2O + 2 ferricytochrome c nitrite + 2 ferrocytochrome c + 5 H+
(2) hydroxylamine + ferricytochrome c nitric oxide + ferrocytochrome c + 3 H+

The enzymes from the nitrifying bacterium Nitrosomonas europaea and the methylotrophic bacterium Methylococcus capsulatus are hemoproteins.

References

  1. ↑ Rees, M. (1968). "Studies of the hydroxylamine metabolism of Nitrosomonas europaea. I. Purification of hydroxylamine oxidase". Biochemistry. 7: 353–366. doi:10.1021/bi00841a045. PMID 5758552.
  2. ↑ Hooper, A.B.; Terry, K.R. (1979). "Hydroxylamine oxidoreductase of Nitrosomonas. Production of nitric oxide from hydroxylamine". Biochim. Biophys. Acta. 571 (1): 12–20. doi:10.1016/0005-2744(79)90220-1. PMID 497235.
  3. ↑ Hooper, A.B.; Balny, C. (1982). "Reaction of oxygen with hydroxylamine oxidoreductase of Nitrosomonas: fast kinetics". FEBS Lett. 144: 299–303. doi:10.1016/0014-5793(82)80658-3. PMID 7117545.
  4. ↑ Lipscomb, J.D.; Hooper, A.B. (1982). "Resolution of multiple heme centers of hydroxylamine oxidoreductase from Nitrosomonas. 1. Electron paramagnetic resonance spectroscopy". Biochemistry. 21: 3965–3972. doi:10.1021/bi00260a010. PMID 6289867.
  5. ↑ Poret-Peterson, A.T.; Graham, J.E.; Gulledge, J.; Klotz, M.G. (2008). "Transcription of nitrification genes by the methane-oxidizing bacterium, Methylococcus capsulatus strain Bath". ISME J. 2 (12): 1213–1220. doi:10.1038/ismej.2008.71. PMID 18650926.
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