Auxiliary Activity family 9

Auxiliary Activity Family 9
Identifiers
Symbol Aux_Act_9
Pfam PF03443
InterPro IPR005103
CAZy AA9

Auxiliary Activity family 9 (formerly GH61) is a family of lytic polysaccharide monooxygenases. The family was previously incorrectly classified as glycoside hydrolase family 61, however it was re-classified in March 2013.[1][2]

AA9 is known to be a copper dependent, oxidative enzyme able to cleave crystalline cellulose.[3] Activity greatly depends on the presence of a divalent copper ion and a reductant such as gallate or ascorbate. The oxidative action of AA9 can work on either the reducing or the non-reducing end of glucose moietes. Although AA9 enzymes can be found in a large spectrum of biomass degrading fungi, research into this family is relatively new.[4] This classification is available on the CAZy web site,[5][6] and also discussed at CAZypedia, an online encyclopedia of carbohydrate active enzymes.[7][8][9]

References

  1. ↑ Levasseur, Anthony; Drula, Elodie; Lombard, Vincent; Coutinho, Pedro M.; Henrissat, Bernard (2013-03-21). "Expansion of the enzymatic repertoire of the CAZy database to integrate auxiliary redox enzymes". Biotechnology for Biofuels. 6: 41. doi:10.1186/1754-6834-6-41. ISSN 1754-6834.
  2. ↑ Hemsworth, Glyn R; Davies, Gideon J; Walton, Paul H. "Recent insights into copper-containing lytic polysaccharide mono-oxygenases". Current Opinion in Structural Biology. 23 (5): 660–668. doi:10.1016/j.sbi.2013.05.006.
  3. ↑ Vaaje-Kolstad, Gustav; Westereng, Bjørge; Horn, Svein J.; Liu, Zhanliang; Zhai, Hong; Sørlie, Morten; Eijsink, Vincent G. H. (2010-10-08). "An Oxidative Enzyme Boosting the Enzymatic Conversion of Recalcitrant Polysaccharides". Science. 330 (6001): 219–222. doi:10.1126/science.1192231. ISSN 0036-8075. PMID 20929773.
  4. ↑ Bey, Mathieu; Zhou, Simeng; Poidevin, Laetitia; Henrissat, Bernard; Coutinho, Pedro M.; Berrin, Jean-Guy; Sigoillot, Jean-Claude (2013-01-15). "Cello-Oligosaccharide Oxidation Reveals Differences between Two Lytic Polysaccharide Monooxygenases (Family GH61) from Podospora anserina". Applied and Environmental Microbiology. 79 (2): 488–496. doi:10.1128/aem.02942-12. ISSN 0099-2240. PMC 3553762. PMID 23124232.
  5. ↑ "Home". CAZy.org. Retrieved 2018-03-06.
  6. ↑ Lombard V, Golaconda Ramulu H, Drula E, Coutinho PM, Henrissat B (January 2014). "The carbohydrate-active enzymes database (CAZy) in 2013". Nucleic Acids Research. 42 (Database issue): D490–5. doi:10.1093/nar/gkt1178. PMID 24270786.
  7. ↑ "Auxiliary Activity Family 9". CAZypedia.org. Retrieved 2018-03-08.
  8. ↑ "Glycoside Hydrolase Family 61". CAZypedia.org. Retrieved 2018-03-06.
  9. ↑ "Ten years of CAZypedia: a living encyclopedia of carbohydrate-active enzymes". Glycobiology. 28 (1): 3–8. December 2018. doi:10.1093/glycob/cwx089. PMID 29040563.
This article incorporates text from the public domain Pfam and InterPro: IPR005103
This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.