Glycine dehydrogenase (cyanide-forming)

glycine dehydrogenase (cyanide-forming)
Identifiers
EC number 1.4.99.5
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / QuickGO

In enzymology, a glycine dehydrogenase (cyanide-forming) (EC 1.4.99.5) is an enzyme that catalyzes the chemical reaction

glycine + 2 A hydrogen cyanide + CO2 + 2 AH2

Thus, the two substrates of this enzyme are glycine and A, whereas its 3 products are hydrogen cyanide, CO2, and AH2.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH2 group of donors with other acceptors. The systematic name of this enzyme class is glycine:acceptor oxidoreductase (hydrogen-cyanide-forming). Other names in common use include hydrogen cyanide synthase, and HCN synthase.

References

    • Wissing F (1975). "Cyanide production from glycine by a homogenate from a Pseudomonas species". J. Bacteriol. 121 (2): 695&ndash, 9. PMC 245984. PMID 234422.
    • Castric PA (1977). "Glycine metabolism by Pseudomonas aeruginosa: hydrogen cyanide biosynthesis". J. Bacteriol. 130 (2): 826&ndash, 31. PMC 235287. PMID 233722.
    • Haas D; Blumer, C; Von Schroetter, C; Gaia, V; Défago, G; Keel, C; Haas, D (1998). "Characterization of the hcnABC gene cluster encoding hydrogen cyanide synthase and anaerobic regulation by ANR in the strictly aerobic biocontrol agent Pseudomonas fluorescens CHA0". J. Bacteriol. 180 (12): 3187&ndash, 96. PMC 107821. PMID 9620970.
    • Blumer C, Haas D (2000). "Mechanism, regulation, and ecological role of bacterial cyanide biosynthesis". Arch. Microbiol. 173 (3): 170&ndash, 7. doi:10.1007/s002039900127. PMID 10763748.


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