Globoside

N-Acetylgalactosamine

A globoside is a type of glycosphingolipid with more than one sugar as the side chain (or R group) of ceramide. The sugars are usually a combination of N-acetylgalactosamine, D-glucose or D-galactose. A glycosphingolipid that has only one sugar as the side chain is called a cerebroside.

The side chain can be cleaved by galactosidases and glucosidases. The deficiency of α-galactosidase A causes Fabry's disease, an inherited metabolic disease characterized by the accumulation of the globoside globotriaosylceramide.^[1]

References

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External links

Globosides at the US National Library of Medicine Medical Subject Headings (MeSH)

Glycoconjugates, lipids and glycolipids: sphingolipids and glycosphingolipids, and metabolic intermediates

Ganglioside
pathway

From ganglioside	GM1 GM2 GM3 GD2
From globoside	Globotriaosylceramide
From sphingomyelin	Glucocerebroside
From sulfatide	Galactocerebroside
To sphingosine	Ceramide

Other

Sphingosine-1-phosphate

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