Fixed drug reaction

Fixed drug reaction
Specialty Dermatology Edit this on Wikidata

Fixed drug reactions, also known as fixed drug eruptions, are common and so named because they recur at the same site with each exposure to a particular medication.[1] Medications inducing fixed drug eruptions are usually those taken intermittently.[1]

Signs and symptoms

A painful purple patch of skin that occurs in the same location with repeated exposures to the culprit drug is the classic presentation of a fixed drug reaction. The lips, genitals, and hands are often involved.

Cause

Medications that are commonly implicated as a cause of fixed drug eruptions include the following:

  1. Fluconazole
  2. Ciprofloxacin
  3. Doxycycline
  4. Clarithromycin
  5. NSAIDs (e.g., ibuprofen)
  6. Trimethoprim
  7. Cotrimoxazole
  8. Phenytoin
  9. Cetirizine
  10. Pseudoephedrine[2]

See also

References

  1. 1 2 James, William; Berger, Timothy; Elston, Dirk (2005). Andrews' Diseases of the Skin: Clinical Dermatology (10th ed.). Saunders. p. 127. ISBN 0-7216-2921-0.
  2. ↑ Vidal, Carmen; Pérez-Carral, Celsa; Armisén, Margarita; Prieto, Azucena (1998). "Nonpigmenting Fixed Drug Eruption due to Pseudoephedrine". Annals of Allergy, Asthma & Immunology. 80 (4): 309–10. doi:10.1016/S1081-1206(10)62974-2. PMID 9564979.
Classification


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