Equine arterivirus serine peptidase
Equine arterivirus serine peptidase | |||||||||
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Identifiers | |||||||||
EC number | 3.4.21.114 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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Equine arterivirus serine peptidase (EC 3.4.21.114) is an enzyme.[1][2][3] This enzyme catalyses the following chemical reaction
- Cleavage of (Glu/Gln)-(Gly/Ser/Ala) in arterivirus replicase translation products ORF1a and ORF1ab
In the equine arterivirus (EAV), the replicase gene is translated into open reading frame 1a (ORF1a) and ORF1ab [polyprotein]s.
References
- ↑ Snijder, E.J.; Wassenaar, A.L.; van Dinten, L.C.; Spaan, W.J.; Gorbalenya, A.E. (1996). "The arterivirus nsp4 protease is the prototype of a novel group of chymotrypsin-like enzymes, the 3C-like serine proteases". J. Biol. Chem. 271: 4864–4871. doi:10.1074/jbc.271.9.4864. PMID 8617757.
- ↑ van Dinten, L.C.; Rensen, S.; Gorbalenya, A.E.; Snijder, E.J. (1999). "Proteolytic processing of the open reading frame 1b-encoded part of arterivirus replicase is mediated by nsp4 serine protease and is essential for virus replication". J. Virol. 73: 2027–2037. PMC 104445. PMID 9971783.
- ↑ Barrette-Ng, I.H.; Ng, K.K.; Mark, B.L.; Van Aken, D.; Cherney, M.M.; Garen, C.; Kolodenko, Y.; Gorbalenya, A.E.; Snijder, E.J.; James, M.N. (2002). "Structure of arterivirus nsp4. The smallest chymotrypsin-like proteinase with an α/β C-terminal extension and alternate conformations of the oxyanion hole". J. Biol. Chem. 277: 39960–39966. doi:10.1074/jbc.m206978200. PMID 12163505.
External links
- Equine+arterivirus+serine+peptidase at the US National Library of Medicine Medical Subject Headings (MeSH)
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