Endo-alpha-sialidase

Endo-alpha-sialidase
Identifiers
EC number 3.2.1.129
CAS number 91195-87-8
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Endo-alpha-sialidase (EC 3.2.1.129, endo-N-acylneuraminidase, endoneuraminidase, endo-N-acetylneuraminidase, poly(alpha-2,8-sialosyl) endo-N-acetylneuraminidase, poly(alpha-2,8-sialoside) alpha-2,8-sialosylhydrolase, endosialidase, endo-N) is an enzyme with systematic name polysialoside (2->8)-alpha-sialosylhydrolase.[1][2][3][4][5][6][7] This enzyme catalyses the following chemical reaction:

Endohydrolysis of (2->8)-alpha-sialosyl linkages in oligo- or poly(sialic) acids

References

  1. ↑ Finne J, Mäkelä PH (January 1985). "Cleavage of the polysialosyl units of brain glycoproteins by a bacteriophage endosialidase. Involvement of a long oligosaccharide segment in molecular interactions of polysialic acid". The Journal of Biological Chemistry. 260 (2): 1265–70. PMID 3968060.
  2. ↑ Hallenbeck PC, Vimr ER, Yu F, Bassler B, Troy FA (March 1987). "Purification and properties of a bacteriophage-induced endo-N-acetylneuraminidase specific for poly-alpha-2,8-sialosyl carbohydrate units". The Journal of Biological Chemistry. 262 (8): 3553–61. PMID 3546309.
  3. ↑ Kitajima K, Inoue S, Inoue Y, Troy FA (December 1988). "Use of a bacteriophage-derived endo-N-acetylneuraminidase and an equine antipolysialyl antibody to characterize the polysialyl residues in salmonid fish egg polysialoglycoproteins. Substrate and immunospecificity studies". The Journal of Biological Chemistry. 263 (34): 18269–76. PMID 3142874.
  4. ↑ Kwiatkowski B, Boschek B, Thiele H, Stirm S (August 1982). "Endo-N-acetylneuraminidase associated with bacteriophage particles". Journal of Virology. 43 (2): 697–704. PMC 256172. PMID 7109038.
  5. ↑ Pelkonen S, Pelkonen J, Finne J (October 1989). "Common cleavage pattern of polysialic acid by bacteriophage endosialidases of different properties and origins". Journal of Virology. 63 (10): 4409–16. PMC 251059. PMID 2778882.
  6. ↑ Tomlinson S, Taylor PW (August 1985). "Neuraminidase associated with coliphage E that specifically depolymerizes the Escherichia coli K1 capsular polysaccharide". Journal of Virology. 55 (2): 374–8. PMC 254943. PMID 3894684.
  7. ↑ Cabezas JA (August 1991). "Some questions and suggestions on the type references of the official nomenclature (IUB) for sialidase(s) and endosialidase". The Biochemical Journal. 278 ( Pt 1): 311–2. doi:10.1042/bj2780311. PMC 1151486. PMID 1883340.
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