Aerobactin synthase

aerobactin synthase
Identifiers
EC number 6.3.2.39
CAS number 94047-30-0
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / QuickGO

In enzymology, an aerobactin synthase (EC 6.3.2.39) is an enzyme that catalyzes the chemical reaction

4 ATP + citrate + 2 N6-acetyl-N6-hydroxy-L-lysine + 2 H2O 4 ADP + 4 phosphate + aerobactin

The 4 substrates of this enzyme are ATP, citrate, N6-acetyl-N6-hydroxy-L-lysine, and H2O, whereas its 3 products are ADP, phosphate, and aerobactin.

This enzyme belongs to the family of ligases, specifically those forming carbon-nitrogen bonds as acid-D-amino-acid ligases (peptide synthases). The systematic name of this enzyme class is citrate:N6-acetyl-N6-hydroxy-L-lysine ligase (ADP-forming). This enzyme is also called citrate:6-N-acetyl-6-N-hydroxy-L-lysine ligase (ADP-forming). This enzyme participates in lysine degradation.

References

    • Appanna DL, Grundy BJ, Szczepan EW & Viswanatha T (1984). "Aerobactin synthesis in a cell-free system of Aerobacter aerogenes 62-1". Biochim. Biophys. Acta. 801: 437&ndash, 443. doi:10.1016/0304-4165(84)90150-8.
    • Gibson F, Magrath DI (1969). "The isolation and characterization of a hydroxamic acid (aerobactin) formed by Aerobacter aerogenes 62-I". Biochim. Biophys. Acta. 192 (2): 175&ndash, 84. doi:10.1016/0304-4165(69)90353-5. PMID 4313071.
    • Maurer PJ & Miller M (1982). "Microbial iron chelators: total synthesis of aerobactin and its constituent amino acid, N6-acetyl-N6-hydroxylysine". J. Am. Chem. Soc. 104 (11): 3096&ndash, 3101. doi:10.1021/ja00375a025.
    • de Lorenzo V, Bindereif A, Paw BH, Neilands JB (1986). "Aerobactin biosynthesis and transport genes of plasmid ColV-K30 in Escherichia coli K-12". J. Bacteriol. 165 (2): 570&ndash, 8. PMC 214457. PMID 2935523.
    • Challis GL (2005). "A widely distributed bacterial pathway for siderophore biosynthesis independent of nonribosomal peptide synthetases". Chembiochem. 6 (4): 601&ndash, 11. doi:10.1002/cbic.200400283. PMID 15719346.


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