Hexaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)

Hexaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)
Identifiers
EC number 2.5.1.83
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Hexaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) (EC 2.5.1.83, HexPS, hexaprenyl pyrophosphate synthetase, hexaprenyl diphosphate synthase) is an enzyme with systematic name (2E,6E)-farnesyl-diphosphate:isopentenyl-diphosphate farnesyltranstransferase (adding 3 isopentenyl units).[1][2][3] This enzyme catalyses the following chemical reaction

(2E,6E)-farnesyl diphosphate + 3 isopentenyl diphosphate 3 diphosphate + all-trans-hexaprenyl diphosphate

The enzyme prefers farnesyl diphosphate to geranylgeranyl diphosphate as an allylic substrate.

References

  1. ↑ Fujii, H.; Koyama, T.; Ogura, K. (1982). "Hexaprenyl pyrophosphate synthetase from Micrococcus luteus B-P 26. Separation of two essential components". J. Biol. Chem. 257 (24): 14610–14612. PMID 7174655.
  2. ↑ Shimizu, N.; Koyama, T.; Ogura, K. (1998). "Molecular cloning, expression, and characterization of the genes encoding the two essential protein components of Micrococcus luteus B-P 26 hexaprenyl diphosphate synthase". J. Bacteriol. 180 (6): 1578–1581. PMC 107062. PMID 9515931.
  3. ↑ Nagaki, M.; Kimura, K.; Kimura, H.; Maki, Y.; Goto, E.; Nishino, T.; Koyama, T. (2001). "Artificial substrates of medium-chain elongating enzymes, hexaprenyl- and heptaprenyl diphosphate synthases". Bioorg. Med. Chem. Lett. 11 (16): 2157–2159. doi:10.1016/S0960-894X(01)00391-2. PMID 11514159.
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