Malonyl CoA reductase (malonate semialdehyde-forming)

Malonyl CoA reductase (malonate semialdehyde-forming)
Identifiers
EC number 1.2.1.75
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Malonyl CoA reductase (malonate semialdehyde-forming) (EC 1.2.1.75, NADP-dependent malonyl CoA reductase, malonyl CoA reductase (NADP)) is an enzyme with systematic name malonate semialdehyde:NADP+ oxidoreductase (malonate semialdehyde-forming).[1][2][3][4] This enzyme catalyse the following chemical reaction

malonate semialdehyde + CoA + NADP+ malonyl-CoA + NADPH + H+

Requires Mg2+. Catalyses the reduction of malonyl-CoA to malonate semialdehyde.

References

  1. ↑ Strauss, G.; Fuchs, G. (1993). "Enzymes of a novel autotrophic CO2 fixation pathway in the phototrophic bacterium Chloroflexus aurantiacus, the 3-hydroxypropionate cycle". Eur. J. Biochem. 215: 633–643. doi:10.1111/j.1432-1033.1993.tb18074.x. PMID 8354269.
  2. ↑ Berg, I.A.; Kockelkorn, D.; Buckel, W.; Fuchs, G. (2007). "A 3-hydroxypropionate/4-hydroxybutyrate autotrophic carbon dioxide assimilation pathway in Archaea". Science. 318: 1782–1786. doi:10.1126/science.1149976. PMID 18079405.
  3. ↑ Alber, B.; Olinger, M.; Rieder, A.; Kockelkorn, D.; Jobst, B.; Hugler, M.; Fuchs, G. (2006). "Malonyl-coenzyme A reductase in the modified 3-hydroxypropionate cycle for autotrophic carbon fixation in archaeal Metallosphaera and Sulfolobus spp". J. Bacteriol. 188 (24): 8551–8559. doi:10.1128/JB.00987-06. PMC 1698253. PMID 17041055.
  4. ↑ Hugler, M.; Menendez, C.; Schagger, H.; Fuchs, G. (2002). "Malonyl-coenzyme A reductase from Chloroflexus aurantiacus, a key enzyme of the 3-hydroxypropionate cycle for autotrophic CO2 fixation". J. Bacteriol. 184 (9): 2404–2410. doi:10.1128/jb.184.9.2404-2410.2002. PMC 134993. PMID 11948153.
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