Carotenoid isomerooxygenase

Carotenoid isomerooxygenase
Identifiers
EC number 1.13.11.65
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Carotenoid isomerooxygenase (EC 1.13.11.65, ninaB (gene)) is an enzyme with systematic name zeaxanthin:oxygen 15,15'-oxidoreductase (bond-cleaving, cis-isomerizing).[1] This enzyme catalyses the following chemical reaction

zeaxanthin + O2 (3R)-11-cis-3-hydroxyretinal + (3R)-all-trans-3-hydroxyretinal

The enzyme from the moth Galleria mellonella and the fruit fly Drosophila melanogaster takes part in the synthesis of retinal .

References

  1. Oberhauser, V.; Voolstra, O.; Bangert, A.; von Lintig, J.; Vogt, K. (2008). "NinaB combines carotenoid oxygenase and retinoid isomerase activity in a single polypeptide". Proc. Natl. Acad. Sci. USA. 105: 19000–19005. doi:10.1073/pnas.0807805105. PMC 2596218. PMID 19020100.
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