Delayed hemolytic transfusion reaction

Delayed hemolytic transfusion reaction

A delayed hemolytic transfusion reaction (DHTR) is a type of transfusion reaction.[1][2][3] It is defined as fever and other symptoms/ signs of hemolysis more than 24 hours after transfusion; confirmed by one or more of the following:

  • a fall in haemoglobin (Hb) level or failure of Hb level to rise after transfusion
  • rise in bilirubin (jaundice)
  • incompatible crossmatch not detectable pre-transfusion.[4]

This can occur up to four weeks after the transfusion.[5]

Delayed blood transfusion reaction occurs more frequently (1 in 20,569 blood components transfused in the USA in 2011) when compared to acute haemolytic transfusion reaction.[6]

One way this can occur is if a person without a Kidd blood antigen receives a Kidd antigen in a transfusion. Other common blood groups with this reaction are Duffy, Rhesus and Kell.[7]

References

  1. ↑ Noizat-Pirenne F, Bachir D, Chadebech P, et al. (December 2007). "Rituximab for prevention of delayed hemolytic transfusion reaction in sickle cell disease". Haematologica. 92 (12): e132–5. doi:10.3324/haematol.12074. PMID 18055978.
  2. ↑ Talano JA, Hillery CA, Gottschall JL, Baylerian DM, Scott JP (June 2003). "Delayed hemolytic transfusion reaction/hyperhemolysis syndrome in children with sickle cell disease". Pediatrics. 111 (6 Pt 1): e661–5. doi:10.1542/peds.111.6.e661. PMID 12777582.
  3. ↑ Elenga N, Mialou V, Kebaïli K, Galambrun C, Bertrand Y, Pondarre C (December 2008). "Severe neurologic complication after delayed hemolytic transfusion reaction in 2 children with sickle cell anemia: significant diagnosis and therapeutic challenges". J. Pediatr. Hematol. Oncol. 30 (12): 928–30. doi:10.1097/MPH.0b013e31818c9172. PMID 19131783.
  4. ↑ Bolton-Maggs, PHB; Poles, D; et al. (Serious Hazards of Transfusion (SHOT) Steering Group) (2017). The 2016 Annual SHOT Report (2017) (PDF). Serious Hazards of Transfusion (SHOT). ISBN 978-0-9558648-9-6.
  5. ↑ "Complications of Transfusion: Transfusion Medicine: Merck Manual Professional".
  6. ↑ "The 2011 National Blood Collection and Utilization Survey Report" (PDF). Department of Health and Human Services. Retrieved 21 January 2016.
  7. ↑ Vassiliki Kazakou, MD; Alexandra Kousoulakou, MD; Euthemia Melissari, MD (2007). "Delayed hemolytic transfusion reaction by a Kidd antibody after heart surgery: Case report and review of the literature". The Journal of thoracic and cardiovascular surgery. 133 (5): 1364–5. doi:10.1016/j.jtcvs.2006.11.022. PMID 17467459. Archived from the original on 2013-04-14.
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