David Eisner (physiologist)

David Eisner
David A. Eisner in 2016
Born David Alfred Eisner
(1955-01-03) 3 January 1955
Manchester[1]
Scientific career
Institutions University College London, University of Liverpool, University of Manchester
Thesis The effects of sodium pump inhibition on the electrical and mechanical properties of mammalian cardiac muscle. (1979)
Doctoral advisor Denis Noble

David Alfred Eisner, FRCP (Hon), FMedSci,[2] (born 3 January 1955)[1][3] is British Heart Foundation Professor of Cardiac Physiology at the University of Manchester and President of The Physiological Society.

Education

After attending Manchester Grammar School, he received his B.A. in Natural Sciences at King's College, Cambridge in 1976. In 1979 he obtained a D.Phil in Physiology at Oxford University in the laboratory of Denis Noble for work on the sodium pump in cardiac muscle.

Career

Following postdoctoral research at the University of Cambridge on the kinetics of the sodium pump[4] in the laboratory of Ian Glynn, he took up a lectureship in the Department of Physiology at University College London in 1980. In 1990 he moved to The University of Liverpool as Professor of Veterinary Biology. In 1999 he took up a Chair of Cardiac Physiology at The University of Manchester and, in 2000 was awarded the BHF Chair of Cardiac Physiology.[5]

Eisner was Chair of The Editorial Board of The Journal of Physiology from 1997–2000[6] and Editor-in Chief of The Journal of Molecular and Cellular Cardiology from 2007–2016.

Research

Eisner's early research focused on the regulation of intracellular sodium in cardiac muscle and the effects on contraction.[7] He then investigated the control of intracellular calcium concentration [8] and its role in the production of arrhythmias.[9] He has identified the factors that regulate the calcium content of the sarcoplasmic reticulum[10][11] and how this is altered in disease.[12]

Honours and awards

Eisner was elected as a Fellow of The Academy of Medical Sciences in 1999[13] and The International Society for Heart Research in 2001.[14] and as a Member of Academia Europaea in 2007.[15] He was elected to Honorary Fellowship of The Royal College of Physicians in 2010. In 2018 he received an honorary doctorate, Doctor Honoris Causa, from The University of Debrecen.[16] Prizes awarded to him include: The GL Brown[17][18] and Annual Review Lecture[19] of The Physiological Society; the Keith Reimer Lecture[20][21] and the Peter Harris Distinguished Scientist Award of the International Society for Heart Research; the Carmeliet-Coraboeuf-Weidmann Lecture of the European Working Group on Cardiac Cellular Electrophysiology.

References

  1. 1 2 "CURRICULUM VITAE – David Alfred Eisner" (PDF). ae-info.org. Academia Europaea. November 2009. Retrieved 30 April 2017.
  2. ↑ "Professor of Cardiac Physiology: Prof David Eisner M.A. D.Phil, FRCP (Hon), FMedSci | The University of Manchester". Research.manchester.ac.uk. Retrieved 2017-04-30.
  3. ↑ ‘EISNER, Prof. David Alfred’, Who's Who 2017, A & C Black, an imprint of Bloomsbury Publishing plc, 2017; online edn, Oxford University Press, 2016 ; online edn, Nov 2016
  4. ↑ D. A. Eisner & D. E. Richards (1981). "The interaction of potassium ions and ATP on the sodium pump of resealed red cell ghosts". The Journal of Physiology. 319: 403–418. doi:10.1113/jphysiol.1981.sp013917. PMC 1243847. PMID 7320919.
  5. ↑ "BHF Professor David Eisner - heart attack and arrhythmias". British Heart Foundation. Retrieved 2017-04-30.
  6. ↑ "Past Officers of the Physiological Society (1876-2001)" (PDF). www.physoc.org. Retrieved 2017-04-30.
  7. ↑ D. A. Eisner, W. J. Lederer & R. D. Vaughan-Jones (1981). "The dependence of sodium pumping and tension on intracellular sodium activity in voltage-clamped sheep Purkinje fibres". The Journal of Physiology. 317: 163–187. doi:10.1113/jphysiol.1981.sp013819. PMC 1246783. PMID 7310731.
  8. ↑ D. G. Allen, D. A. Eisner & C. H. Orchard (1984). "Factors influencing free intracellular calcium concentration in quiescent ferret ventricular muscle". The Journal of Physiology. 350: 615–630. PMC 1199289. PMID 6747860.
  9. ↑ C. H. Orchard, D. A. Eisner & D. G. Allen (1983). "Oscillations of intracellular Ca2+ in mammalian cardiac muscle". Nature. 304 (5928): 735–738. doi:10.1038/304735a0. PMID 6888540.
  10. ↑ D. A. Eisner, A. W. Trafford, M. E. Diaz, C. L. Overend & S. C. O'Neill (1998). "The control of Ca release from the cardiac sarcoplasmic reticulum: regulation versus autoregulation". Cardiovascular research. 38 (3): 589–604. doi:10.1016/s0008-6363(98)00062-5. PMID 9747428.
  11. ↑ A. W. Trafford, M. E. Diaz & D. A. Eisner (February 2001). "Coordinated control of cell Ca(2+) loading and triggered release from the sarcoplasmic reticulum underlies the rapid inotropic response to increased L-type Ca(2+) current". Circulation Research. 88 (2): 195–201. doi:10.1161/01.res.88.2.195. PMID 11157672.
  12. ↑ Takeshi Kashimura, Sarah J. Briston, Andrew W. Trafford, Carlo Napolitano, Silvia G. Priori, David A. Eisner & Luigi A. Venetucci (2010). "In the RyR2(R4496C) mouse model of CPVT, beta-adrenergic stimulation induces Ca waves by increasing SR Ca content and not by decreasing the threshold for Ca waves". Circulation Research. 107 (12): 1483–1489. doi:10.1161/CIRCRESAHA.110.227744. PMID 20966392.
  13. ↑ "Professor David Eisner | The Academy of Medical Sciences". Acmedsci.ac.uk. Retrieved 2017-04-30.
  14. ↑ "Fellows of the ISHR". International Society for Heart Research. Retrieved 2017-04-30.
  15. ↑ "Academy of Europe: Eisner David". Ae-info.org. Retrieved 2017-04-30.
  16. ↑ születnek, www.WebDeb.hu - ahol a weblapok. "University of Debrecen -". edu.unideb.hu. Retrieved 2018-06-15.
  17. ↑ "GL Brown Prize Lecture | Physiological Society". Physoc.org. 2011-05-29. Retrieved 2017-04-30.
  18. ↑ "Calcium in the heart: from physiology to disease - David Eisner (GL Brown Lecture 2014)". YouTube. 2014-05-16. Retrieved 2017-04-30.
  19. ↑ Eisner, David A. (2018-01-01). "Ups and downs of calcium in the heart". The Journal of Physiology. 596 (1): 19–30. doi:10.1113/JP275130. ISSN 1469-7793. PMID 29071725.
  20. ↑ "ISHR Hall of Fame". International Society for Heart Research. Retrieved 2017-04-30.
  21. ↑ Eisner DA, Kashimura T, O'Neill SC, Venetucci LA, Trafford AW (2017-02-03). "What role does modulation of the ryanodine receptor play in cardiac inotropy and arrhythmogenesis?". J Mol Cell Cardiol. 46: 474–81. doi:10.1016/j.yjmcc.2008.12.005. PMID 19150449.
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