Chris J. Leaver
| Chris Leaver CBE FRS FRSE | |
|---|---|
| Born |
Christopher John Leaver 31 May 1942[1] |
| Education | Lyme Regis Grammar School |
| Alma mater | Imperial College London (BSc, PhD)[2] |
| Awards | EMBO Member[3] |
| Scientific career | |
| Institutions | |
| Thesis | The correlation between nucleic acid synthesis and induced enzyme activity in plant tissue slices (1966) |
| Doctoral students | Ian A. Graham[4][5] |
| Influences | Anthony Trewavas |
| Influenced | David Baulcombe[6] |
| Website |
www |
Christopher John Leaver CBE FRS FRSE (born 31 May 1942) is a British biochemist and Emeritus Professor in the Department of Plant Sciences at the University of Oxford[7][8][9] and an Emeritus Fellow, of St John's College, Oxford.[10]
Education
Leaver was educated at Lyme Regis Grammar School and Imperial College London[1] where he was awarded a Bachelor of Science followed by a PhD in Plant Physiology in 1966.[2]
Career and research
Leaver's area of expertise is in plant biochemistry, development, plant physiology and signalling;[11][12] before his current positions, he has at the Department of Botany and Plant Pathology at Purdue University[13] and the University of Edinburgh.[14][15] During his career, Leaver held the following positions:
- Botanist Imperial College Hornsund Expedition,[16] Spitzbergen, 1962 and Beerenberg Expedition, Jan Mayen, 1963.
- Fulbright Scholar, Purdue University, USA, 1966–68.
- University of Edinburgh 1969–90: Lecturer, then Reader 1980,
- Science and Engineering Research Council (SERC) Senior Research Fellow 1985–90
- Professor of Plant Molecular Biology 1986–1990.
- University of Oxford Sibthorpian Professor of Plant Science, 1990–2007.
- Head of Department 1991–2007.
- Fellow of St John’s College, Oxford 1990–
- Emeritus Professor of Plant Science, University of Oxford 2008–
Awards and honours
Leaver was elected a Fellow of the Royal Society (FRS) in 1986.[17] His nomination reads
| “ | Distinguished for his contributions to unravelling the role of nucleic acids in the development of higher plants. Leaver was the first person to isolate nucleic acids from higher plants in 1964, and produced the first description of the pathway of cytoplasmic ribosomal RNA synthesis. He discovered a novel species of 4.5S RNA in chloroplast ribosomes, and with W, Bottomley developed the coupled transcription-translation system now used in the analysis of chloroplast DNA. He established that the synthesis of glyoxysomal enzymes in cucumber seedlings is under transcriptional control. His more recent and innovative work concerns the structure, information content and expression of the plant mitochondrial genome, a field he has pioneered. He was the first to isolate plant mitochondrial ribosomes, establish their unique RNA composition, and develop the standard system now used for protein synthesis by isolated plant mitochondria. His work has produced strong evidence linking the agriculturally important trait of cytoplasmic male sterility in maize and sorghum with mutations in the mitochondrial genome which lead to the production of variant polypeptides. As well as isolating several protein-encoding plant mitochondrial genes, he has identified, cloned and sequenced the first nuclear gene for a plant mitochondrial protein.[17] | ” |
He was awarded EMBO Membership in 1982.[3]
References
- 1 2
LEAVER, Prof. Christopher John. ukwhoswho.com. Who's Who. 2017 (online Oxford University Press ed.). A & C Black, an imprint of Bloomsbury Publishing plc.
- 1 2 Leaver, Christopher John (1966). The correlation between nucleic acid synthesis and induced enzyme activity in plant tissue slices. london.ac.uk (PhD thesis). University of London (Queen Elizabeth College and Imperial College of Science and Technology). OCLC 681131873.
- 1 2 "EMBO Member: Christopher J. Leaver". people.embo.org. European Molecular Biology Organization. Archived from the original on 5 August 2017.
- ↑ Graham, Ian Alexander (1989). Structure and function of the cucumber malate synthase gene and expression during plant development (PhD thesis). University of Edinburgh. hdl:1842/12057.
- ↑ Graham, Ian A.; Smith, Laura M.; Brown, John W. S.; Leaver, Christopher J.; Smith, Steven M. (1989). "The malate synthase gene of cucumber". Plant Molecular Biology. 13 (6): 673–684. doi:10.1007/BF00016022. PMID 2491683.
- ↑ Baulcombe, David (1976). The processing and intracellular transport of messenger RNA in a higher plant. ethos.bl.uk (PhD thesis). University of Edinburgh. hdl:1842/14914.
- ↑ Balk, J.; Leaver, C.; McCabe, P. (1999). "Translocation of cytochrome c from the mitochondria to the cytosol occurs during heat-induced programmed cell death in cucumber plants". FEBS Letters. 463 (1–2): 151–154. doi:10.1016/S0014-5793(99)01611-7. PMID 10601657.
- ↑ Alpi, A.; Amrhein, N.; Bertl, A.; Blatt, M.; Blumwald, E.; Cervone, F.; Dainty, J.; De Michelis, M.; Epstein, E.; Galston, A. W.; Goldsmith, M. H. M.; Hawes, C.; Hell, R. D.; Hetherington, A.; Hofte, H.; Juergens, G.; Leaver, C. J.; Moroni, A.; Murphy, A.; Oparka, K.; Perata, P.; Quader, H.; Rausch, T.; Ritzenthaler, C.; Rivetta, A.; Robinson, D. G.; Sanders, D.; Scheres, B.; Schumacher, K.; Sentenac, H. (2007). "Plant neurobiology: no brain, no gain?". Trends in Plant Science. 12 (4): 135–136. doi:10.1016/j.tplants.2007.03.002. PMID 17368081.
- ↑ Swidzinski, J.; Sweetlove, L.; Leaver, C. (2002). "A custom microarray analysis of gene expression during programmed cell death in Arabidopsis thaliana". The Plant Journal. 30 (4): 431–446. doi:10.1046/j.1365-313x.2002.01301.x. PMID 12028573.
- ↑ Chris J. Leaver publications indexed by the Scopus bibliographic database. (subscription required)
- ↑ Fox, T. D.; Leaver, C. J. (1981). "The zea mays mitochondrial gene coding cytochrome oxidase subunit II has an intervening sequence and does not contain TGA codons". Cell. 26 (3): 315–323. doi:10.1016/0092-8674(81)90200-2. PMID 6276012.
- ↑ May, M. J.; Vernoux, T.; Leaver, C.; Montagu, M. V.; Inze, D. (1998). "Glutathione homeostasis in plants: Implications for environmental sensing and plant development". Journal of Experimental Botany. 49 (321): 649–667. doi:10.1093/jxb/49.321.649.
- ↑ Leaver, C.; Key, J. (1967). "Polyribosome formation and RNA synthesis during aging of carrot-root tissue". Proceedings of the National Academy of Sciences of the United States of America. 57 (5): 1338–1344. doi:10.1073/pnas.57.5.1338. PMC 224477. PMID 5231738.
- ↑ Leaver, C.; Ingle, J. (1971). "The molecular integrity of chloroplast ribosomal ribonucleic acid". The Biochemical Journal. 123 (2): 235–243. doi:10.1042/bj1230235. PMC 1176928. PMID 5001778.
- ↑ Trewavas, A; Leaver, CJ (2001). "Is opposition to GM crops science or politics? An investigation into the arguments that GM crops pose a particular threat to the environment". EMBO Reports. 2 (6): 455–9. doi:10.1093/embo-reports/kve123. PMC 1083916. PMID 11415971.
- ↑ Anon (2009). "Imperial College Hornsund Expedition, 1962". Polar Record. 11 (74): 596. doi:10.1017/S0032247400055728.
- 1 2 Anon (1986). "EC/1986/22: Leaver, Christopher John". Royal Society. Archived from the original on 4 January 2014.
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