Chondroitin ABC lyase

Chondroitin ABC lyase
Identifiers
EC number 4.2.2.4
CAS number 9024-13-9
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Chondroitin ABC lyase (EC 4.2.2.4, chondroitinase, chondroitin ABC eliminase, chondroitinase ABC) is an enzyme with systematic name chondroitin ABC lyase.[1][2] This enzyme catalyses the following chemical reaction

Eliminative degradation of polysaccharides containing 1,4-beta-D-hexosaminyl and 1,3-beta-D-glucuronosyl or 1,3-alpha-L-iduronosyl linkages to disaccharides containing 4-deoxy-beta-D-gluc-4-enuronosyl groups

This enzyme acts on chondroitin 4-sulfate, chondroitin 6-sulfate and dermatan sulfate.

Uses

Following a spinal cord injury, this enzyme can be used to erode scar tissue that can interfere with regeneration.[3]

References

  1. ↑ Yamagata T, Saito H, Habuchi O, Suzuki S (April 1968). "Purification and properties of bacterial chondroitinases and chondrosulfatases". The Journal of Biological Chemistry. 243 (7): 1523–35. PMID 5647268.
  2. ↑ Saito H, Yamagata T, Suzuki S (April 1968). "Enzymatic methods for the determination of small quantities of isomeric chondroitin sulfates". The Journal of Biological Chemistry. 243 (7): 1536–42. PMID 4231029.
  3. ↑ Bartus K, James ND, Didangelos A, Bosch KD, Verhaagen J, Yáñez-Muñoz RJ, Rogers JH, Schneider BL, Muir EM, Bradbury EJ (April 2014). "Large-scale chondroitin sulfate proteoglycan digestion with chondroitinase gene therapy leads to reduced pathology and modulates macrophage phenotype following spinal cord contusion injury". The Journal of Neuroscience. 34 (14): 4822–36. doi:10.1523/JNEUROSCI.4369-13.2014. PMC 3972714. PMID 24695702. Lay summary – Eureka Alert.
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