Chinmoy Sankar Dey

Chinmoy Sankar Dey
Born (1961-03-18) 18 March 1961
Kolkata, West Bengal, India
Residence New Delhi, India
Nationality Indian
Alma mater
Known for Studies on insulin resistance
Awards
Scientific career
Fields
Institutions

Chinmoy Sankar Dey (born 18 March 1961) is an Indian molecular biologist and a professor at Kusuma School of Biological Sciences of the Indian Institute of Technology, Delhi. Known for his research on insulin resistance, Dey's is a J. C. Bose National Fellow of the Department of Science and Technology and an elected fellow of the National Academy of Sciences, India and the Indian National Science Academy. The Council of Scientific and Industrial Research, the apex agency of the Government of India for scientific research, awarded him the Shanti Swarup Bhatnagar Prize for Science and Technology, one of the highest Indian science awards for his contributions to Medical Sciences in 2003. He is also a recipient of the National Bioscience Award for Career Development of the Department of Biotechnology.

Biography

University of Calcutta

S. C. Dey was born on 18 March 1961 in Kolkata, the capital of the Indian state of West Bengal.[1] He graduated in zoology from the University of Calcutta in 1982 and continued at the institution to obtain a master's degree in 1984.[2] Afterwards, he joined the Indian Institute of Chemical Biology, in Kolkata, as a research fellow for his doctoral studies and submitted his thesis Biochemical regulation of sperm motility, which earned him a PhD from Jadavpur University in 1990.[3] He did his post-doctoral studies initially at California Institute of Technology from 1988 to 1991 as a post-doc research fellow and later, at the Baylor College of Medicine, as a post-doc research associate from 1991 to 1992. On his return to India in 1992, he started his career by joining the National Institute of Immunology as a pool officer, but his stay there lasted only for two years. In 1994, he moved to National Institute of Pharmaceutical Education and Research, Mohali as an assistant professor at the department of biotechnology where he served for over a decade and a half. During this period, he held positions as an associate professor (1999–2002) as well as a professor (2002–10), and he became head of the department in 2004. In 2010, he moved his base to New Delhi to join the Indian Institute of Technology at Kusuma School of Biological Sciences as a professor[4][5] and is the head of the Central Research Facility.[6] He leads a laboratory at IIT Delhi involved in research on Insulin-resistant diabetes and hosts a number of scholars and students.[7] He also serves as a visiting scientist at Madras Diabetes Research Foundation (MDRF).[8]

Legacy

Dey's research has been focusing on the drug resistance of two diseases, leishmaniasis and diabetes.[3] His work on insulin resistance included the development of an in-vitro model, which has potential applications in screening anti-diabetic drugs.[9][10] The model, which involved insulin-resistant cultured skeletal muscle cells, earned him a US patent.[11] Using the model in tandem with biochemical and gene silencing methodologies, he demonstrated that focal adhesion kinases and p38 mitogen-activated protein kinases could be used as possible drug targets.[12] His team identified for the first time the apoptosis-like cell death in Type II topoisomerase and suggested the enzyme as a possible treatment protocol for Leishmaniasis.[3] His findings were published in a 2005 article in Molecular and Biochemical Parasitology of Elsevier.[13] He also proposed eIF4A, a member of a set of three related proteins, as a drug target to combat infection with Leishmania donovani, a Miltefosine-resistant type of trypanosome causing leishmaniasis.[3] His work on myogenesis and muscular dystrophy showed insulin‑mediated dephosphorylation of PTK2 (focal adhesion kinase) could be stopped by inhibiting the activity of the insulin receptor tyrosine kinase, which was a new discovery.[12] His research has been documented in numerous articles;[14][note 1] ResearchGate, an online repository of scientific articles, lists 90 of them.[15] Besides this he has contributed chapters to two books,[16][17] and his work has drawn citations from other researchers.[18][19][20] James Watson, a recipient of the Nobel Prize in Physiology or Medicine in 1962, cited one of Dey's papers in his 2013 lecture at University of California, Los Angeles to commemorate the 60th anniversary of the discovery of double helical structure DNA,[1] which was later published as an article in Lancet in 2014.[21] He also holds a Patent Cooperation Treaty and his aforementioned US patent, as well as two Indian patents, and has guided students in their master's and doctoral studies.[12]

Dey was the Sectional Secretary of the 91st Indian Science Congress held in 2003; he was also associated with the organization of the Indo‑US Symposium on Recombinant DNA Technology and Its Application in Drug Discovery held at BITS, Pilani in February 1999 and the workshops on Molecular Basis of Drug Discovery and on Molecular Modeling and Pharmainformatics held at National Institute of Pharmaceutical Education and Research, Mohali in 2005.[12] He was the regional associate editor of the Journal of Biopharmaceutics and Biotechnology in 2006 and is a former member of the editorial boards of the now defunct Open Parasitology Journal of Bentham Science Publishers and Scientific Reports of Nature Publishing Group.[1] He is a reviewer for Molecular Biology International, a journal of the Hindawi Publishing Corporation,[22] the Diabetes journal of the American Diabetes Association, The FASEB Journal, the Molecular Medicine journal, FEBS Letters, the Journal of Molecular Cell Biology, Antimicrobial Agents and Chemotherapy, the British Journal of Pharmacology, Comparative Biochemistry and Physiology, Expert Opinion on Biological Therapy, the Indian Journal of Medical Research, and Experimental Parasitology. He has also served as an adviser or consultant to pharmaceutical companies such as Orchid Chemicals and Pharmaceutical Ltd., TCG Lifesciences (former Chembiotek Research International) and DSM Anti-Infectives.[2]

Awards and honors

The Council of Scientific and Industrial Research awarded him Shanti Swarup Bhatnagar Prize, one of the highest Indian science awards in 2003.[23] The same year, he also received the National Bioscience Award for Career Development of the Department of Biotechnology,[24] followed by the OPPI Award of the Organisation of Pharmaceutical Producers of India in 2005.[25] He became an elected fellow of two major Indian science academies in 2007: the National Academy of Sciences, India[26] and the Indian National Science Academy.[27] He received two honors in 2008: the CDRI Award of the Central Drug Research Institute[28] and the J. C. Bose National Fellowship of the Department of Biotechnology.[29][30] In 2011, he was awarded the inaugural Honor Lecture Award by Madras Diabetes Research Foundation.[8] He is also a life member of the Society of Biological Chemists, India.[1]

Selected bibliography

Book chapters

  • Shio Kumar Singh (editor); G. C. Majumdar, S. C. Dey, S. Saha, K. Das, D. Nath. A. Maiti, S. Dey, D. Roy; S. Mitra, A. Rana, J. Chakrabarty, S. Das, A. Bhoumik, S. Banerjee, M. Mandal, B. S. Jaiswal, P. Ghosh, A. Das, D. Bhattacharyya, S. R. Dungdung (chapter authors) (4 September 2015). "Role of Sperm Surface Molecules in Motility Regulation". Mammalian Endocrinology and Male Reproductive Biology. CRC Press. pp. 197–. ISBN 978-1-4987-2736-5.
  • Shio Kumar Singh (editor); S. C. Dey (chapter author) (4 September 2015). Mammalian Endocrinology and Male Reproductive Biology. CRC Press. pp. 14–. ISBN 978-1-4987-2736-5.

Articles

  • Hira Lal Goel, Chinmoy Sankar Dey (2002). "Insulin stimulates spreading of skeletal muscle cells involving the activation of focal adhesion kinase, phosphatidylinositol 3-kinase and extracellular signal regulated kinases". Journal of Cellular Physiology. 193 (2): 187–198. doi:10.1002/jcp.10161.
  • Hira Lal Goel, Chinmoy Sankar Dey (2002). "Role of protein kinase C during insulin mediated skeletal muscle cell spreading". Journal of Muscle Research & Cell Motility. 23 (4): 269–277. doi:10.1023/A:1022028808806.
  • Bisht B, Goel HL, Dey CS (2007). "Focal adhesion kinase regulates insulin resistance in skeletal muscle". Diabetologia. 50 (5): 1058–69. doi:10.1007/s00125-007-0591-6.
  • Bisht B, Dey CS (2008). "Focal Adhesion Kinase contributes to insulin-induced actin reorganization into a mesh harboring Glucose transporter-4 in insulin resistant skeletal muscle cells". BMC Cell Biol. 9 (48). doi:10.1186/1471-2121-9-48.
  • Gupta A, Bisht B, Dey CS (2011). "Peripheral insulin-sensitizer drug metformin ameliorates neuronal insulin resistance and Alzheimer's-like changes". Neuropharmacology. 60 (6): 910–20. doi:10.1016/j.neuropharm.2011.01.033.
  • Amit Gupta, Chinmoy Sankar Dey (2012). "PTEN, a widely known negative regulator of insulin/PI3K signaling, positively regulates neuronal insulin resistance". Mol Biol Cell. 23 (19): 3882–3898. doi:10.1091/mbc.E12-05-0337. PMC 3459864.
  • Aakash Gautam Mukhopadhyay, Chinmoy Sankar Dey (2016). "Reactivation of flagellar motility in demembranated Leishmania reveals role of cAMP in flagellar wave reversal to ciliary waveform". Scientific Reports. 6. doi:10.1038/srep37308.

Patents

  • Chinmoy Sankar Dey (30 May 2006). "Skeletal cell model to screen anti-diabetic compounds". US Patent No. 7052910. Justia Patents.

See also

Notes

  1. ↑ See also "Selected bibliography" section

References

  1. 1 2 3 4 "Faculty Profile A" (PDF). Bioschool, IIT Delhi. 2017. Archived from the original (PDF) on 27 March 2017. Retrieved 26 March 2017.
  2. 1 2 "Faculty Profile B". Bioschool, IIT Delhi. 2017.
  3. 1 2 3 4 "Indian fellow". Indian National Science Academy. 2017.
  4. ↑ "Faculty". Bioschool, IIT Delhi. 2017.
  5. ↑ "Chinmoy Shankar Dey : Biological Sciences". IIT Delhi. 2017.
  6. ↑ "Contact Us". Central Research Facility, IIT Delhi. 2017.
  7. ↑ "Chinmoy S. Dey's Lab". Bioschool, IIT Delhi. 2017.
  8. 1 2 "MDRF honours IIT Delhi professor". News 18. 22 July 2011. Missing or empty |url= (help)
  9. ↑ "Brief Profile of the Awardee". Shanti Swarup Bhatnagar Prize. 2017.
  10. ↑ "Handbook of Shanti Swarup Bhatnagar Prize Winners" (PDF). Council of Scientific and Industrial Research. 1999. p. 71.
  11. ↑ Chinmoy Sankar Dey (30 May 2006). "Skeletal cell model to screen anti-diabetic compounds". US Patent No. 7052910. Justia Patents.
  12. 1 2 3 4 "Shanti Swarup Bhatnagar Prize‑winner Prof. Chinmoy Sankar Dey's Work". NISCAIR. 2017.
  13. ↑ Singh G, Jayanarayan KG, Dey CS (May 2005). "Novobiocin induces apoptosis-like cell death in topoisomerase II over-expressing arsenite resistant Leishmania donovani". Mol Biochem Parasitol. 141 (1): 57–69. doi:10.1016/j.molbiopara.2005.01.014. PMID 15811527.
  14. ↑ "Scholarly Contributions". Hindawi. 2017.
  15. ↑ "On ResearchGate". On ResearchGate. 2017.
  16. ↑ Shio Kumar Singh (editor); G. C. Majumdar, S. C. Dey, S. Saha, K. Das, D. Nath. A. Maiti, S. Dey, D. Roy; S. Mitra, A. Rana, J. Chakrabarty, S. Das, A. Bhoumik, S. Banerjee, M. Mandal, B. S. Jaiswal, P. Ghosh, A. Das, D. Bhattacharyya, S. R. Dungdung (chaper authors) (4 September 2015). "Role of Sperm Surface Molecules in Motility Regulation". Mammalian Endocrinology and Male Reproductive Biology. CRC Press. pp. 197–. ISBN 978-1-4987-2736-5.
  17. ↑ Shio Kumar Singh (editor); S. C. Dey (chapter author) (4 September 2015). Mammalian Endocrinology and Male Reproductive Biology. CRC Press. pp. 14–. ISBN 978-1-4987-2736-5.
  18. ↑ Vanete Thomaz Soccol; Ashok Pandey; Rodrigo R. Resende (17 September 2016). Current Developments in Biotechnology and Bioengineering: Human and Animal Health Applications. Elsevier Science. pp. 588–. ISBN 978-0-444-63671-3.
  19. ↑ Studies in Natural Products Chemistry. Newnes. 15 March 2013. pp. 427–. ISBN 978-0-444-62609-7.
  20. ↑ Hemanta K. Majumder (15 September 2008). Drug Targets in Kinetoplastid Parasites. Springer Science & Business Media. pp. 7–. ISBN 978-0-387-77570-8.
  21. ↑ "Type 2 diabetes as a redox disease" (PDF). Lancet. 383: 841–43. 2014. doi:10.1016/s0140-6736(13)62365-x.
  22. ↑ "Molecular Biology International". Hindawi. 2017. Archived from the original on 2017-03-27.
  23. ↑ "Medical Sciences". Council of Scientific and Industrial Research. 2017. Archived from the original on 2013-02-24.
  24. ↑ "Awardees of National Bioscience Awards for Career Development" (PDF). Department of Biotechnology. 2016.
  25. ↑ "OPPI Award". NIPER. 2017.
  26. ↑ "NASI Year Book 2015" (PDF). National Academy of Sciences, India. 2017. Archived from the original (PDF) on 2015-08-06.
  27. ↑ "INSA Year Book 2016" (PDF). Indian National Science Academy. 2017.
  28. ↑ "CDRI Award". Central Drug Research Institute. 2017.
  29. ↑ "J C Bose fellowship". NIPER. 2017.
  30. ↑ "NASI fellows". National Academy of Sciences, India. 2017. Archived from the original on 2015-07-17.
  • "Dey CS [Author]". List of PubMed articles. US National Library of Medicine. 2017.
  • "Skeletal cell model to screen anti-diabetic compounds". TMP searchers. 2017. p. Indian patent details.
  • "View Bhatnagar Awardees". Shanti Swarup Bhatnagar Prize. 2016. Retrieved 12 November 2016.

Further reading

  • Amit Gupta, Chinmoy Sankar Dey (2017). "PTEN, a widely known negative regulator of insulin/PI3K signaling, positively regulates neuronal insulin resistance" (PDF). Article (full text). American Society for Cell Biology.
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