Cellosaurus

Cellosaurus
Content
Description Cellosaurus: a knowledge resource on cell lines
Data types
captured		 Cell lines
Organisms Vertebrate, Insect, Tick
Contact
Research center Swiss Institute of Bioinformatics
Laboratory CALIPHO
Authors Amos_Bairoch
Access
Data format Flat file database, OBO and XML
Website web.expasy.org/cellosaurus/
Download URL ftp://ftp.expasy.org/databases/cellosaurus
Tools
Web Search
Miscellaneous
License Creative Commons Attribution-NoDerivs
Versioning Yes
Data release
frequency		 4 to 6 releases per year
Curation policy Yes - manual
Bookmarkable
entities		 Yes - individual cell line entries

Cellosaurus is an on-line knowledge resource on cell lines [1]. It is provided by the Swiss Institute of Bioinformatics (SIB) as one of its contribution [2] to ELIXIR. It is the contributing resource for cell lines on the Resource Identification Portal [3].

Its scope includes immortalised cell lines, naturally immortal cell lines (example: embryonic stem cells) and finite life cell lines when those are distributed and used widely. The Cellosaurus provides a wealth of manually curated information; for each cell line it lists a recommended name, synonyms and the species of origin. Other types of information include standardised disease terminology (for cancer or genetic disorder cell lines), the transformant used to immortalise a cell line, transfected or knocked-out genes, microsatellite instability, doubling time, gender and age of donor (patient or animal), important sequence variations, web links, publication references and cross-references to more than 70 different databases, ontologies, cell collections and other relevant resources.

Since many cell lines used in research have been misidentified or contaminated, the Cellosaurus keeps track of problematic cell lines, including all those listed in the International Cell Line Authentication Committee (ICLAC) [4] tables.

For human as well as some dog cell lines, it provides short tandem repeat (STR) profile information.

Since July 2018, all cell lines in the Cellosaurus are represented as items in Wikidata.

It is developed by Amos Bairoch at the CALIPHO group [5] of the Swiss Institute of Bioinformatics (SIB).

References

  1. ↑ Bairoch Amos (2018). "The Cellosaurus, a cell-line knowledge resource". Journal of Biomolecular Techniques. 29 ([Epub ahead of print): 1–14. doi:10.7171/jbt.18-2902-002. PMC 5945021. PMID 29805321.
  2. ↑ https://www.elixir-europe.org/services/cellosaurus
  3. ↑ https://scicrunch.org/resources/Cell%20Lines/source/SCR_013869-1/search?q=%2A&l=
  4. ↑ http://iclac.org/wp-content/uploads/Cross-Contaminations-v8_0.pdf
  5. ↑ CALIPHO group, on the web site of the SIB
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