C-terminal processing peptidase

C-terminal processing peptidase
Identifiers
EC number 3.4.21.102
CAS number 92480-11-0&title= 216484-75-2, 92480-11-0
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

C-terminal processing peptidase (EC 3.4.21.102, CtpA gene product (Synechocystis sp.), photosystem II D1 protein processing peptidase, protease Re, tail-specific protease, Tsp protease) is an enzyme.[1][2][3] This enzyme catalyses the following chemical reaction

The enzyme shows specific recognition of a C-terminal tripeptide, Xaa-Yaa-Zaa, in which Xaa is preferably Ala or Leu, Yaa is preferably Ala or Tyr, and Zaa is preferably Ala, but then cleaves at a variable distance from the C-terminus. A typical cleavage is -Ala-Ala!Arg-Ala-Ala-Lys-Glu-Asn-Tyr-Ala-Leu-Ala-Ala. In the plant chloroplast, the enzyme removes the C-terminal extension of the X1 polypeptide of photosystem II

Proteolytic processing of the X1 protein of photosystem II anables light-driven assembly of the tetranuclear manganese cluster.

References

  1. ↑ Keiler KC, Sauer RT (1998). "Tsp protease". In Barrett AJ, Rawlings ND, Woessner JF. Handbook of Proteolytic Enzymes. London: Handbook of Proteolytic Enzymes. pp. 460–461.
  2. ↑ Beebe KD, Shin J, Peng J, Chaudhury C, Khera J, Pei D (March 2000). "Substrate recognition through a PDZ domain in tail-specific protease". Biochemistry. 39 (11): 3149–55. doi:10.1021/bi992709s. PMID 10715137.
  3. ↑ Liao DI, Qian J, Chisholm DA, Jordan DB, Diner BA (September 2000). "Crystal structures of the photosystem II D1 C-terminal processing protease". Nature Structural Biology. 7 (9): 749–53. doi:10.1038/78973. PMID 10966643.
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