Biotin—(propionyl-CoA-carboxylase (ATP-hydrolyzing)) ligase
| biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] ligase | |||||||||
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| Identifiers | |||||||||
| EC number | 6.3.4.10 | ||||||||
| CAS number | 37318-67-5 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, a biotin-[propionyl-CoA-carboxylase (ATP-hydrolysing)] ligase (EC 6.3.4.10) is an enzyme that catalyzes the chemical reaction
- ATP + biotin + apo-propionyl-CoA:carbon-dioxide ligase (ADP-forming) AMP + diphosphate + propionyl-CoA:carbon-dioxide ligase (ADP-forming)
The 3 substrates of this enzyme are ATP, biotin, and [[apo-[propionyl-CoA:carbon-dioxide ligase (ADP-forming)]], whereas its 3 products are AMP, diphosphate, and propionyl-CoA:carbon-dioxide ligase (ADP-forming).
This enzyme belongs to the family of ligases, specifically those forming generic carbon-nitrogen bonds. The systematic name of this enzyme class is biotin:apo-[propanoyl-CoA:carbon-dioxide ligase (ADP-forming)] ligase (AMP-forming). Other names in common use include biotin-[propionyl-CoA-carboxylase (ATP-hydrolysing)] synthetase, biotin-propionyl coenzyme A carboxylase synthetase, and propionyl coenzyme A holocarboxylase synthetase. This enzyme participates in biotin metabolism.
References
- Siegel L, Foote JL, Coon MJ (1965). "The enzymatic synthesis of propionyl coenzyme A holocarboxylase from d-biotinyl 5'-adenylate and the apocarboxylase". J. Biol. Chem. 240: 1025–1031. PMID 14284697.