Beta-amyrin synthase

Beta-amyrin synthase
Identifiers
EC number 5.4.99.39
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Beta-amyrin synthase (EC 5.4.99.39, 2,3-oxidosqualene beta-amyrin cyclase, AsbAS1, BPY, EtAS, GgbAS1, LjAMY1, MtAMY1, PNY, BgbAS) is an enzyme with systematic name (3S)-2,3-epoxy-2,3-dihydrosqualene mutase (cyclizing, beta-amyrin-forming).[1][2][3][4][5][6][7][8][9][10][11] This enzyme catalyses the following chemical reaction

(3S)-2,3-epoxy-2,3-dihydrosqualene beta-amyrin

Some organism possess a monofunctional beta-amyrin synthase.

References

  1. ↑ Abe I, Ebizuka Y, Seo S, Sankawa U (1989). "Purification of squalene-2,3-epoxide cyclases from cell suspension cultures of Rabdosia japonica Hara". FEBS Lett. 249: 100–104. doi:10.1016/0014-5793(89)80024-9.
  2. ↑ Abe I, Sankawa U, Ebizuka Y (1989). "Purification of 2,3-oxdosqualene:β-amyrin cyclase from pea seedlings". Chem. Pharm. Bull. 37: 536-. doi:10.1248/cpb.37.536.
  3. ↑ Kushiro T, Shibuya M, Ebizuka Y (August 1998). "Beta-amyrin synthase--cloning of oxidosqualene cyclase that catalyzes the formation of the most popular triterpene among higher plants". European Journal of Biochemistry. 256 (1): 238–44. doi:10.1046/j.1432-1327.1998.2560238.x. PMID 9746369.
  4. ↑ Hayashi H, Huang P, Kirakosyan A, Inoue K, Hiraoka N, Ikeshiro Y, Kushiro T, Shibuya M, Ebizuka Y (August 2001). "Cloning and characterization of a cDNA encoding beta-amyrin synthase involved in glycyrrhizin and soyasaponin biosyntheses in licorice". Biological & Pharmaceutical Bulletin. 24 (8): 912–6. doi:10.1248/bpb.24.912. PMID 11510484.
  5. ↑ Husselstein-Muller T, Schaller H, Benveniste P (January 2001). "Molecular cloning and expression in yeast of 2,3-oxidosqualene-triterpenoid cyclases from Arabidopsis thaliana". Plant Molecular Biology. 45 (1): 75–92. doi:10.1023/A:1006476123930. PMID 11247608.
  6. ↑ Iturbe-Ormaetxe I, Haralampidis K, Papadopoulou K, Osbourn AE (March 2003). "Molecular cloning and characterization of triterpene synthases from Medicago truncatula and Lotus japonicus". Plant Molecular Biology. 51 (5): 731–43. doi:10.1023/a:1022519709298. PMID 12683345.
  7. ↑ Zhang H, Shibuya M, Yokota S, Ebizuka Y (May 2003). "Oxidosqualene cyclases from cell suspension cultures of Betula platyphylla var. japonica: molecular evolution of oxidosqualene cyclases in higher plants". Biological & Pharmaceutical Bulletin. 26 (5): 642–50. doi:10.1248/bpb.26.642. PMID 12736505.
  8. ↑ Hayashi H, Huang P, Takada S, Obinata M, Inoue K, Shibuya M, Ebizuka Y (July 2004). "Differential expression of three oxidosqualene cyclase mRNAs in Glycyrrhiza glabra". Biological & Pharmaceutical Bulletin. 27 (7): 1086–92. doi:10.1248/bpb.27.1086. PMID 15256745.
  9. ↑ Kajikawa M, Yamato KT, Fukuzawa H, Sakai Y, Uchida H, Ohyama K (August 2005). "Cloning and characterization of a cDNA encoding beta-amyrin synthase from petroleum plant Euphorbia tirucalli L". Phytochemistry. 66 (15): 1759–66. doi:10.1016/j.phytochem.2005.05.021. PMID 16005035.
  10. ↑ Basyuni M, Oku H, Tsujimoto E, Kinjo K, Baba S, Takara K (October 2007). "Triterpene synthases from the Okinawan mangrove tribe, Rhizophoraceae". The FEBS Journal. 274 (19): 5028–42. doi:10.1111/j.1742-4658.2007.06025.x. PMID 17803686.
  11. ↑ Liu Y, Cai Y, Zhao Z, Wang J, Li J, Xin W, Xia G, Xiang F (May 2009). "Cloning and Functional Analysis of a beta-amyrin synthase gene associated with oleanolic acid biosynthesis in Gentiana straminea MAXIM". Biological & Pharmaceutical Bulletin. 32 (5): 818–24. doi:10.1248/bpb.32.818. PMID 19420748.
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