Basophilia

Basophilia
Pronunciation
  • bā-sə-ˈfi-lē-ə
Specialty Hematology Edit this on Wikidata

Basophilia is a condition derived from Basophils. It is characterized by an abnormal abundance (more than 1010 (10 billion) basophils per liter of blood) of Basophils in the bloodstream.[1] Basophilia is associated with pruritus (itching) due to the release of histamine.[2]

Signs and Symptoms

  • Signs and Symptoms for Allergies[3]:
    • Sneezing
    • Runny Nose/ Stuff Nose
    • Hives
    • Rash
    • Swelling of the mouth and throat
    • Nausea/ Vomiting
    • Trouble Breathing
    • Itchy
  • Signs and Symptoms for Inflammation[4]:
    • Coughing
    • Fever
    • Fatigue
    • Headache
    • Loss of appetite/ Change in appetite
  • Signs and Symptoms for Myeloproliferative Disorders[5]:
    • Fatigue
    • Weakness
    • Fever
    • Unexplained weight loss
    • Easy bleeding/ bruising
    • Bloating
    • Bone Pain
    • Abdominal Pain
    • Changes in vision/ Blurred vision

Causes

Generally linked to allergic/hypersensitivity disorders or chronic inflammatory conditions

Blood Smear

These conditions can include:

  • Allergy or inflammation
  1. Ulcerative colitis
  2. Drug, food, inhalant hypersensitivity
  3. Erythroderma, urticaria
  4. Juvenile rheumatoid arthritis
  5. Hay Fever
  1. Diabetes mellitus
  2. Estrogen administration
  • Infection
  1. Chicken pox
  2. Influenza
  3. Smallpox
  4. Tuberculosis
  1. "Basophilic leukemia" (see text)

Physiology

Basophil is a type of Granulocyte, White Blood Cell/ Leukocyte (WBCs) that provides immunity and defense for our bodies from viruses, bacteria, and foreign objects. It is associated to interleukin (IL)-3, IL-5, and granulocyte-monocyte-colony stimulating factor (GM-CSF)[6] through a release of synthesis-storing Histamine and Heparin that occupies about 0.5-1% of the circulating WBCs. Can also be characterized by an unsegmented/ bilobed shaped nucleus with purplish-black/ deep blue cytoplasmic granules. It averages about 8-10 micrometer.

Diagnosis

Basophilia can be detected through a complete blood count (CBC) to determine if there is an abnormal amount in the bloodstream (more than 10 billion basophils per liter of blood).

Basophilia can also by diagnosed through a bone marrow biopsy, genetic testing to look for genetic mutations, or ultrasound to determine enlargement of the spleen.

Treatment

Basophilia is not likely to be treated directly. Instead, treatments will focus on the person’s underlying medical treatment.

Treatments for underlying medical conditions include:

  • Medications
  • Chemotherapy/ Radiation
  • Surgery to remove enlarged spleen

Animals

Eosinophilia and Basophilia are the most common abnormalities in dogs[7].

References

  1. ↑ "Cytoplasmic basophilia". Veterinary Clinical Pathology Image Database. University of Montreal Veterinary College. Retrieved 2008-09-20.
  2. ↑ Interactive, Wellfire. "Pathology Thread". www.med-ed.virginia.edu. Retrieved 2016-04-07.
  3. ↑ "Basophilia: Definition, Symptoms, and Causes". Healthline. Retrieved 2018-05-10.
  4. ↑ "Basophilia: Definition, Symptoms, and Causes". Healthline. Retrieved 2018-05-10.
  5. ↑ "Basophilia: Definition, Symptoms, and Causes". Healthline. Retrieved 2018-05-10.
  6. ↑ Themes, UFO (2016-06-13). "Basophilia". Basicmedical Key. Retrieved 2018-05-10.
  7. ↑ "Basophilia - an overview". ScienceDirect. Retrieved 2018-05-10.
Classification
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