CFU-GM

CFU-GM
Lineage. Captions in Polish, but "GMP" visible near bottom center.
Details
Gives rise to Monoblasts and myeloblasts
Location Bone marrow
Function colony forming unit
Identifiers
TH H2.00.04.3.02009
Anatomical terms of microanatomy

CFU-GM (or "GMP", for "granulocyte-macrophage progenitor") is a colony forming unit. It is derived from CFU-GEMM.

The "GM" stands for "granulocyte, monocyte".[1]

It is the precursor for monoblasts and myeloblasts.

Production is stimulated by granulocyte macrophage colony-stimulating factor (GM-CSF).

Granulocytes

There is some controversy over which granulocytes derive from CFU-GM.

  • There is little disagreement that neutrophils come from CFU-GM.
  • Some sources state that basophils also derive from CFU-GM, but that eosinophils come from "CFU-Eos".[2]
  • Other sources state that basophils do not derive from CFU-GM, but from a distinct CFU, titled "CFU-Baso".[3]

See also

References

  1. ↑ "Hem I WBC Morphology and Physiology". Archived from the original on December 25, 2008. Retrieved 2008-12-30.
  2. ↑ Ganong, William F.; McPhee, Stephen J.; Lingappa, Vishwanath R. (2005). Pathophysiology of Disease: An Introduction to Clinical Medicine (Lange). McGraw-Hill Medical. p. 107. ISBN 0-07-144159-X.
  3. ↑ Rudolph, Colin David (2003). Rudolph's pediatrics. New York: McGraw-Hill, Medical Pub. Division. p. 1563. ISBN 0-8385-8285-0.


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