Avatrombopag

Avatrombopag
Clinical data
Trade names	Doptelet
Routes of; administration	Oral
Identifiers
	IUPAC name 1-[3-Chloro-5-[[4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)-1,3-thiazol-2-yl]carbamoyl]pyridin-2-yl]piperidine-4-carboxylic acid;
CAS Number	570406-98-3 ;
PubChem CID	9852519;
ChemSpider	8028230 ;
UNII	3H8GSZ4SQL;
ChEMBL	CHEMBLCHEMBL2103883 ;
Chemical and physical data
Formula	C29H34Cl2N6O3S2
Molar mass	649.65 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C1CCC(CC1)N2CCN(CC2)C3=C(N=C(S3)NC(=O)C4=CC(=C(N=C4)N5CCC(CC5)C(=O)O)Cl)C6=CC(=CS6)Cl;
	InChI InChI=1S/C29H34Cl2N6O3S2/c30-20-15-23(41-17-20)24-27(37-12-10-35(11-13-37)21-4-2-1-3-5-21)42-29(33-24)34-26(38)19-14-22(31)25(32-16-19)36-8-6-18(7-9-36)28(39)40/h14-18,21H,1-13H2,(H,39,40)(H,33,34,38) ; Key:OFZJKCQENFPZBH-UHFFFAOYSA-N;
(what is this?)

Avatrombopag is a medication that has been developed for certain conditions that lead to thrombocytopenia (abnormally low platelet counts) such as thrombocytopenia associated with chronic liver disease in adult patients who are to undergo a planned medical or dental procedure. It was approved by the Food and Drug Administration in May 21, 2018.^[1]

References

↑ FDA approves new drug for patients with chronic liver disease who have low blood platelets and are undergoing a medical procedure

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[1] FDA approves new drug for patients with chronic liver disease who have low blood platelets and are undergoing a medical procedure

Clinical data

Trade names	Doptelet
Routes of administration	Oral
Identifiers
IUPAC name 1-[3-Chloro-5-[[4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)-1,3-thiazol-2-yl]carbamoyl]pyridin-2-yl]piperidine-4-carboxylic acid
CAS Number	570406-98-3^N
PubChem CID	9852519
ChemSpider	8028230^Y
UNII	3H8GSZ4SQL
ChEMBL	CHEMBLCHEMBL2103883^N
Chemical and physical data
Formula	C₂₉H₃₄Cl₂N₆O₃S₂
Molar mass	649.65 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES C1CCC(CC1)N2CCN(CC2)C3=C(N=C(S3)NC(=O)C4=CC(=C(N=C4)N5CCC(CC5)C(=O)O)Cl)C6=CC(=CS6)Cl
InChI InChI=1S/C29H34Cl2N6O3S2/c30-20-15-23(41-17-20)24-27(37-12-10-35(11-13-37)21-4-2-1-3-5-21)42-29(33-24)34-26(38)19-14-22(31)25(32-16-19)36-8-6-18(7-9-36)28(39)40/h14-18,21H,1-13H2,(H,39,40)(H,33,34,38)^Y Key:OFZJKCQENFPZBH-UHFFFAOYSA-N
^NY (what is this?)