Antonín Holý

Antonín Holý
Born (1936-09-01)September 1, 1936
Prague, Czechoslovakia
Died July 16, 2012(2012-07-16) (aged 75)
Prague, Czech Republic
Nationality Czech
Alma mater Charles University in Prague
Known for Antiretroviral drugs used in the treatment of HIV
Spouse(s) Ludmila Holá
Scientific career
Fields Chemist
Institutions Czechoslovak Academy of Sciences (1960 – 1992)
Academy of Sciences of the Czech Republic (1992 – 2002)

Antonín Holý (1 September 1936 – 16 July 2012) was a pioneering Czech scientist. He specialised in the field of chemistry and cooperated on the development of important antiretroviral drugs used in the treatment of HIV and hepatitis B. He was involved in the creation of the most effective drug (as of early 2009) in the treatment of AIDS.[1] Antonín Holý is the author of more than 400 scientific discoveries and holds 60 patents.[2] With more than 400 discoveries to his credit, his work has affected millions of people with viral diseases such as HIV/AIDS and hepatitis B and many other viral diseases.[3] In 2008 he received an Honorary Professorship at the University of Manchester's School of Chemistry.[4]

Scientific career

Born in Prague, Czechoslovakia, Antonín Holý studied organic chemistry from 1954 to 1959 at the Faculty of Science of Charles University in Prague. From 1960 he trained at the Institute of Organic Chemistry and Biochemistry (IOCB) of the Czechoslovak Academy of Sciences in Prague and has been a researcher there since 1963. He became the Institute's lead scientist in 1967, and from 1983 headed its working group for nucleic acids. In 1987 he became chief of the Department of Nucleic Acid Chemistry and from 1994 to 2002 he was head of the IOCB.

Since 1976 he has collaborated on the development of new antiretroviral drugs with Erik De Clercq of the Rega Institute for Medical Research at the Catholic University of Leuven, Belgium.[5]

In 2006 the US biopharmaceutical company Gilead Sciences and the Institute of Organic Chemistry and Biochemistry (IOCB) of the Academy of Sciences of the Czech Republic jointly established a new research center, oriented to the development of new preparations.[5] Gilead promised the IOCB a $1.1 million donation, to fund its operations and research for 5 years.[6]

Several antiretroviral drugs based on Holý's discoveries have been licensed. In 1996, Vistide was approved for production in the United States and European Union. Viread (tenofovir) was approved in the USA in 2001 for the treatment of AIDS, and Hepsera was approved in 2003 for the treatment of hepatitis B. Truvada, a combination of Viread and emtricitabine, was approved in 2006 for use in the USA.[7]

Death

Holý had retired a year before his death and died of an unspecified cause, aged 75, on 16 July 2012. A statement from the IOCB called his death "an immense loss".[8][9] His death occurred two months after the U.S. Food and Drug Administration (FDA) approved Truvada for treating HIV,[3] the same day that FDA approved Truvada for HIV prevention.

Awards and honours

  • 1984 State Prize for Chemistry (Acyklická analoga nukleosidů a nukleotidů)
  • 1998 Hanuš's Medal of the Czech Chemical Society
  • 1999 Honorary doctorate of the Palacký University in Olomouc
  • 2001 Descartes Prize of the European Union;[2] The Medal of Merit of the Czech Republic (Za zásluhy) I. degree
  • 2003 Honorary membership in the Rega Institute for Medical Research, Catholic University of Leuven, Belgium.
  • 2004 Award Praemium Bohemiae;[10] Medal of the Czech Academy of Sciences: De scientia et humanitate optime meritis
  • 2005 Honorary doctorate of the Ghent University (Belgium); The Medal of Merit of the Faculty of Science at the Charles University in Prague.
  • 2006 Member of the European Academy of Sciences and Arts (Salzburg)
  • 2006 Honorary doctorate of the Institute of Chemical Technology, Prague
  • 2007 State Prize "Czech Head" (Česká hlava)

See also

Notes

  1. ↑ "Faces of the Presidency". EU2009.cz. Retrieved 8 January 2009.
  2. 1 2 "Czech Chemistry: A Tradition of Innovation and Prosperity". Association for Foreign Investment. Archived from the original on 18 July 2011. Retrieved 8 January 2009.
  3. 1 2 "Groundbreaking chemist Antonín Holý dies at 75". Radio Prague. 17 July 2012. Retrieved 17 July 2012.
  4. ↑ "Antonín Holý received a Honorary Professorship of School of Chemistry". Academic bulletin. Archived from the original on 27 January 2010. Retrieved 8 January 2009.
  5. 1 2 "Gilead Sciences and the Institute of Organic Chemistry and Biochemistry (IOCB) Establish New Academic Research Centre in Prague; Donation by Gilead Honors Leadership of Dr. Antonin Holy in Antiviral Drug Discovery and Development". Gilead. Retrieved 8 January 2009.
  6. ↑ "Gilead Sciences and the Institute of Organic Chemistry and Biochemistry (IOCB) Establish New Academic Research Centre in Prague". ZoomInfo. Retrieved 8 January 2009.
  7. ↑ "Truvada (tenofovir + emtricitabine)". AIDSmeds.com. Archived from the original on 10 January 2009. Retrieved 8 January 2009.
  8. ↑ "Zemřel světoznámý chemik Antonín Holý, objevitel léků pro miliony lidí". Mladá fronta DNES (in Czech). iDnes. 17 July 2012. Retrieved 17 July 2012.
  9. ↑ "HIV drug developer Antonin Holy dies". CBC.ca. Retrieved 17 July 2012.
  10. ↑ "Praemium Bohemiae podruhé" (in Czech). Academic Bulletin. Retrieved 8 January 2009.
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