Angiomotin-like protein 1

AMOTL1
Identifiers
AliasesAMOTL1, JEAP, angiomotin like 1
External IDsMGI: 1922973 HomoloGene: 43977 GeneCards: AMOTL1
Gene location (Human)
Chr.Chromosome 11 (human)[1]
Band11q21Start94,706,431 bp[1]
End94,876,753 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

154810

75723

Ensembl

ENSG00000166025

ENSMUSG00000013076

UniProt

Q8IY63

Q9D4H4

RefSeq (mRNA)

NM_001301007
NM_130847

NM_001081395

RefSeq (protein)

NP_001287936
NP_570899
NP_570899.1

NP_001074864

Location (UCSC)Chr 11: 94.71 – 94.88 MbChr 9: 14.54 – 14.65 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Angiomotin-like protein 1 is a protein that in humans is encoded by the AMOTL1 gene.[5][6]

Function

The protein encoded by this gene is a peripheral membrane protein that is a component of tight junctions or TJs. TJs form an apical junctional structure and act to control paracellular permeability and maintain cell polarity. This protein is related to angiomotin, an angiostatin binding protein that regulates endothelial cell migration and capillary formation.[6]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000166025 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000013076 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Nishimura M, Kakizaki M, Ono Y, Morimoto K, Takeuchi M, Inoue Y, Imai T, Takai Y (Feb 2002). "JEAP, a novel component of tight junctions in exocrine cells". J Biol Chem. 277 (7): 5583–7. doi:10.1074/jbc.M110154200. PMID 11733531.
  6. 1 2 "Entrez Gene: AMOTL1 angiomotin like 1".

Further reading

  • Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
  • Bratt A, Wilson WJ, Troyanovsky B, et al. (2003). "Angiomotin belongs to a novel protein family with conserved coiled-coil and PDZ binding domains". Gene. 298 (1): 69–77. doi:10.1016/S0378-1119(02)00928-9. PMID 12406577.
  • Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
  • Patrie KM (2005). "Identification and characterization of a novel tight junction-associated family of proteins that interacts with a WW domain of MAGI-1". Biochim. Biophys. Acta. 1745 (1): 131–44. doi:10.1016/j.bbamcr.2005.05.011. PMID 16019084.
  • Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.


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