Alpha-muurolene synthase
Alpha-muurolene synthase | |||||||||
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Identifiers | |||||||||
EC number | 4.2.3.125 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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Alpha-muurolene synthase (EC 4.2.3.125, Cop3) is an enzyme with systematic name (2E,6E)-farnesyl-diphosphate diphosphate-lyase (cyclizing, alpha-muurolene-forming).[1][2] This enzyme catalyses the following chemical reaction
- (2E,6E)-farnesyl diphosphate alpha-muurolene + diphosphate
The enzyme has been characterized from the fungus Coprinus cinereus.
References
- ↑ Agger, S.; Lopez-Gallego, F.; Schmidt-Dannert, C. (2009). "Diversity of sesquiterpene synthases in the basidiomycete Coprinus cinereus". Mol. Microbiol. 72: 1181–1195. doi:10.1111/j.1365-2958.2009.06717.x. PMC 2723806. PMID 19400802.
- ↑ Lopez-Gallego, F.; Wawrzyn, G.T.; Schmidt-Dannert, C. (2010). "Selectivity of fungal sesquiterpene synthases: role of the active site’s H-1α loop in catalysis". Appl. Environ. Microbiol. 76: 7723–7733. doi:10.1128/aem.01811-10. PMC 2988597. PMID 20889795.
External links
- Alpha-muurolene+synthase at the US National Library of Medicine Medical Subject Headings (MeSH)
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