Alpha-eudesmol synthase

Alpha-eudesmol synthase
Identifiers
EC number 4.2.3.85
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Alpha-eudesmol synthase (EC 4.2.3.85) is an enzyme with systematic name (2E,6E)-farnesyl-diphosphate diphosphate-lyase (alpha-eudesmol-forming).[1] This enzyme catalyses the following chemical reaction

(2E,6E)-farnesyl diphosphate + H2O alpha-eudesmol + diphosphate

The recombinant enzyme from ginger (Zingiber zerumbet) gives beta-eudesmol, 10-epi-gamma-eudesmol, alpha-eudesmol and aristolene.

References

  1. Yu, F.; Harada, H.; Yamasaki, K.; Okamoto, S.; Hirase, S.; Tanaka, Y.; Misawa, N.; Utsumi, R. (2008). "Isolation and functional characterization of a β-eudesmol synthase, a new sesquiterpene synthase from Zingiber zerumbet Smith". FEBS Lett. 582: 565–572. doi:10.1016/j.febslet.2008.01.020. PMID 18242187.
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