Alexandra Worden

Alexandra Zoe Worden
Alexandra Z. Worden in 2017
Born Middlesex County, Massachusetts, United States
Residence Santa Cruz, California, United States
Nationality American
Known for work on Biogeochemical cycling, Evolutionary biology
Scientific career
Fields Microbiology, Oceanography
Institutions Monterey Bay Aquarium Research Institute
Doctoral advisor Brian Binder

Alexandra (Alex) Z. Worden (born 1970) is a marine microbial ecologist and genome scientist. She leads the microbial ecology research group at the Monterey Bay Aquarium Research Institute where she holds the position of Senior Scientist. Her laboratory also bridges with the Ocean Sciences Department at the University of California Santa Cruz where she is Professor Adjunct.

Worden’s research focuses on the physiology and ecology of eukaryotic phytoplankton, unicellular organisms that are responsible for a large portion of ocean primary production (photosynthetic uptake of atmospheric carbon dioxide). Worden’s early work focused on methods development for directly investigating populations in the nature environment and their roles in the carbon cycle.[1][2] This theme has persisted throughout her research career.

As a postdoctoral fellow at Scripps Institution of Oceanography Worden was recognized for establishing the importance of small eukaryotic phytoplankton known as picoeukaryotes.[3][4] A second study by Worden while in the laboratory of Farooq Azam overturned the idea that Vibrio cholerae existed primarily attached to copepods in aquatic systems.[5] This was considered important for understanding ecology of this human pathogen and vectors for transmission of infective cells. She and Azam also introduced the concept of Ecosystems Biology (also spelled Eco-systems Biology or (Eco)-systems Biology), coining the term in a 2004 perspective.[6] The concept was embraced by the scientific community in several later perspectives,[7][8] and is being pursued by human microbiome-biologist Jeroen Raes and microbial oceanographer Edward DeLong. A Jacques Monod conference on Marine Eco-Systems Biology was initiated in 2015.[9]

Worden pioneered eukaryotic "targeted metagenomics" [10][11][12] wherein cells of particular interest are separated from the masses using flow cytometry (on a ship) and genomes are then sequenced from only the cells of greatest interest. Using this approach Worden and collaborators at the DOE Joint Genome Institute sequenced partial genomes from uncultured eukaryotic algae whilst showing the distribution of these photosynthetic protists in the ocean. Her laboratory also investigates ancestral components of land plants,[13] evolutionary biology and distributions of uncultured taxa[14][15] and interactions between viruses and phytoplankton host cells. In 2015, she and co-authors called for a "rethinking of the marine carbon cycle".[16] Worden publishes in the fields of environmental microbiology, evolutionary biology, genome science and oceanography.

She is a proponent of STEM education and innovation and has highlighted the need for relevant "...role models to inspire greater diversity and creativity" in science.[17]

Career

Worden started her laboratory in 2004 as Assistant Professor at the Rosenstiel School of Marine and Atmospheric Science in Miami, Florida USA. In 2004 she was also awarded a Young Investigator in Marine Microbiology Award[18] by the Gordon and Betty Moore Foundation. In 2007 she was hired to build a microbial ecology research group at MBARI on the U.S. West Coast under the leadership of Marcia McNutt. In 2009, Worden was named a scholar of the Canadian Institute for Advanced Research (CIFAR), later becoming a fellow of CIFAR (2011). She became a GBMF Marine Investigator in 2013, an award given for her "creativity, innovation, and potential to make major, new breakthroughs"[19] and was elected as a Fellow of the American Academy of Microbiology in 2016.[20]

Education

Worden attended Wellesley College, where she received a B.A. in history, and performed a concentration in Earth, Atmospheric and Planetary Sciences coursework at the Massachusetts Institute of Technology. At the latter she worked in the laboratories of John M. Edmond,[21] Reginald Newell and Sallie W. Chisholm. Worden received her Ph.D. from the Odum School of Ecology in 2000. Engineering is a component of her oceanographic research. Worden's initial engineering exposure was through computer programming and work after high school at BBN Technologies and with the MIT solar electric car project. The team included several individuals who leading innovators in the tech world, including Gill Pratt[22] and Megan Smith, and was led by her brother James Worden.[23][24][25]

Family

Worden has a partner and two children.[26][27]

See also

References

  1. ↑ "European Commission : CORDIS : News and Events : Green genes provide insights into climate change". cordis.europa.eu.
  2. ↑ DOE Joint Genome Institute (16 October 2008). "JGI Community Faces: Alexandra Z. Worden" – via YouTube.
  3. ↑ Worden Alexandra Z. "Assessing the dynamics and ecology of marine picophytoplankton: The importance of the eukaryotic component". Limnology and Oceanography. 49 (1): 168–179. CiteSeerX 10.1.1.527.5206. doi:10.4319/lo.2004.49.1.0168.
  4. ↑ "Research" (PDF). cell.com.
  5. ↑ Worden AZ, Seidel M, Smriga S, Wick A, Malfatti F, Bartlett D, Azam F (2006). "Trophic regulation of Vibrio cholerae in coastal marine waters". Environmental Microbiology. 8 (1): 21&ndash, 29. doi:10.1111/j.1462-2920.2005.00863.x. PMID 16343318.
  6. ↑ Azam, F; Worden, A. Z. (2004). "Oceanography. Microbes, molecules, and marine ecosystems". Science. 303 (5664): 1622–4. doi:10.1126/science.1093892. PMID 15016987.
  7. ↑ Raes, J; Bork, P (2008). "Molecular eco-systems biology: Towards an understanding of community function". Nature Reviews Microbiology. 6 (9): 693–9. doi:10.1038/nrmicro1935. PMID 18587409.
  8. ↑ Karsenti, E; Acinas, S. G.; Bork, P; Bowler, C; De Vargas, C; Raes, J; Sullivan, M; Arendt, D; Benzoni, F; Claverie, J. M.; Follows, M; Gorsky, G; Hingamp, P; Iudicone, D; Jaillon, O; Kandels-Lewis, S; Krzic, U; Not, F; Ogata, H; Pesant, S; Reynaud, E. G.; Sardet, C; Sieracki, M. E.; Speich, S; Velayoudon, D; Weissenbach, J; Wincker, P; The Tara Oceans, Consortium (2011). "A Holistic Approach to Marine Eco-Systems Biology". PLoS Biology. 9 (10): e1001177. doi:10.1371/journal.pbio.1001177. PMC 3196472. PMID 22028628.
  9. ↑ "CNRS - Conférences Jacques Monod 2015". www.cnrs.fr.
  10. ↑ Cuvelier ML; et al. (2010). "Targeted metagenomics and ecology of globally important uncultured eukaryotic phytoplankton". Proc Natl Acad Sci U S A. 107 (33): 14679&ndash, 84. Bibcode:2010PNAS..10714679C. doi:10.1073/pnas.1001665107. PMC 2930470. PMID 20668244.
  11. ↑ Raven JA (2012). "Algal biogeography: metagenomics shows distribution of a picoplanktonic pelagophyte". Current Biology. 22 (17): R675&ndash, 7. doi:10.1016/j.cub.2012.07.030. PMID 22974994.
  12. ↑ Martin, Cyrus (20 April 2015). "Biology's dark matter". Current Biology. 25 (8): R301–R307. doi:10.1016/j.cub.2015.03.010.
  13. ↑ Archibald JM (2009). "Green Evolution, Green Revolution". Science. 324 (5924): 191&ndash, 192. Bibcode:2009Sci...324..191A. doi:10.1126/science.1172972.
  14. ↑ redOrbit (21 January 2011). "Biologists Find New Group Of Algae Living In Fresh And Salt Water - Redorbit". redorbit.com.
  15. ↑ http://www.sea-technology.com/news/archives/2011/mar_resources/mar_resources0311.php Archived 2012-01-24 at the Wayback Machine. SeaTechnology Magazine Article on newly discovered algae
  16. ↑ Worden, A. Z.; Follows, M. J.; Giovannoni, S. J.; Wilken, S; Zimmerman, A. E.; Keeling, P. J. (2015). "Environmental science. Rethinking the marine carbon cycle: Factoring in the multifarious lifestyles of microbes". Science. 347 (6223): 1257594. doi:10.1126/science.1257594. PMID 25678667.
  17. ↑ "Volume 27 Issue 04 Supplement - Oceanography". www.tos.org.
  18. ↑ http://aslo.org/bulletin/04_v13_i4.pdf ASLO Bulletin Vol 13 (4) December 2004
  19. ↑ "Mini Microbes Make A Big Splash - Good Times Santa Cruz". goodtimes.sc.
  20. ↑ Urban, Joanna. "78 Fellows Elected to the American Academy of Microbiology". www.asm.org.
  21. ↑ "JOHN EDMOND". web.mit.edu.
  22. ↑ "Gill Pratt Discusses Toyota's AI Plans and the Future of Robots and Cars". IEEE Spectrum: Technology, Engineering, and Science News.
  23. ↑ Wald, Matthew L. "Profile; In Quest for Electric Cars, He Adds the Power of Faith". nytimes.com.
  24. ↑ "Solectria – Achieving Goals By Lowering Them". wordpress.com. 28 July 2014.
  25. ↑ "Solar car sets world record - The Tech". tech.mit.edu.
  26. ↑ "Alexandra Worden and the eukaryote tree of life". aaas.org. 10 June 2016.
  27. ↑ "Bio". asm.org.

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