Aldos-2-ulose dehydratase

Aldos-2-ulose dehydratase
Identifiers
EC number 4.2.1.110
CAS number 101920-80-3
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Aldos-2-ulose dehydratase (EC 4.2.1.110, pyranosone dehydratase, AUDH, 1,5-anhydro-D-fructose dehydratase (microthecin-forming)) is an enzyme with systematic name 1,5-anhydro-D-fructose hydro-lyase (microthecin-forming).[1][2][3][4][5] This enzyme catalyses the following chemical reaction

1,5-anhydro-D-fructose 2-hydroxy-2-(hydroxymethyl)-2H-pyran-3(6H)-one + H2O (overall reaction)
(1a) 1,5-anhydro-D-fructose 1,5-anhydro-4-deoxy-D-glycero-hex-3-en-2-ulose + H2O
(1b) 1,5-anhydro-4-deoxy-D-glycero-hex-3-en-2-ulose 2-hydroxy-2-(hydroxymethyl)-2H-pyran-3(6H)-one

This enzyme catalyses two of the steps in the anhydrofructose pathway.

References

  1. ↑ Yu, S.; Fiskesund, R. (2006). "The anhydrofructose pathway and its possible role in stress response and signaling". Biochim. Biophys. Acta. 1760: 1314–1322. doi:10.1016/j.bbagen.2006.05.007. PMID 16822618.
  2. ↑ Yu, S. (2005). "Enzymatic description of the anhydrofructose pathway of glycogen degradation. II. Gene identification and characterization of the reactions catalyzed by aldos-2-ulose dehydratase that converts 1,5-anhydro-D-fructose to microthecin with ascopyrone M as the intermediate". Biochim. Biophys. Acta. 1723: 63–73. doi:10.1016/j.bbagen.2005.01.004. PMID 15716041.
  3. ↑ Broberg, A.; Kenne, L.; Pedersén, M. (1996). "Presence of microthecin in the red alga Gracilariopsis lemaneiformis and its formation from 1,5-anhydro-D-fructose". Phytochemistry. 41: 151–154. doi:10.1016/0031-9422(95)00587-0.
  4. ↑ Gabriel, J.; Volc, J.; Sedmera, P.; Daniel, G.; Kubátová, E. (1993). "Pyranosone dehydratase from the basidiomycete Phanerochaete chrysosporium: improved purification, and identification of 6-deoxy-D-glucosone and D-xylosone reaction products". Arch. Microbiol. 160 (1): 27–34. doi:10.1007/BF00258142. PMID 8352649.
  5. ↑ Yu, S.; Refdahl, C.; Lundt, I. (2004). "Enzymatic description of the anhydrofructose pathway of glycogen degradation; I. Identification and purification of anhydrofructose dehydratase, ascopyrone tautomerase and α-1,4-glucan lyase in the fungus Anthracobia melaloma". Biochim. Biophys. Acta. 1672: 120–129. doi:10.1016/j.bbagen.2004.03.004. PMID 15110094.
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