Aldehyde dehydrogenase 9 family, member A1

ALDH9A1
Identifiers
AliasesALDH9A1, ALDH4, ALDH7, ALDH9, E3, TMABADH, aldehyde dehydrogenase 9 family member A1
External IDsMGI: 1861622 HomoloGene: 55483 GeneCards: ALDH9A1
EC number1.2.1.3
Gene location (Human)
Chr.Chromosome 1 (human)[1]
Band1q24.1Start165,662,216 bp[1]
End165,698,863 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

223

56752

Ensembl

ENSG00000143149

ENSMUSG00000026687

UniProt

P49189

Q9JLJ2

RefSeq (mRNA)

NM_000696

NM_019993

RefSeq (protein)

NP_000687

NP_064377

Location (UCSC)Chr 1: 165.66 – 165.7 MbChr 1: 167.35 – 167.37 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

4-trimethylaminobutyraldehyde dehydrogenase is an enzyme that in humans is encoded by the ALDH9A1 gene.[5][6][7]

This protein belongs to the aldehyde dehydrogenase family of proteins. It has a high activity for oxidation of gamma-aminobutyraldehyde and other amino aldehydes. The enzyme catalyzes the dehydrogenation of gamma-aminobutyraldehyde to gamma-aminobutyric acid (GABA). This isozyme is a tetramer of identical 54-kD subunits.[7]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000143149 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000026687 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ McPherson JD, Wasmuth JJ, Kurys G, Pietruszko R (Mar 1994). "Human aldehyde dehydrogenase: chromosomal assignment of the gene for the isozyme that metabolizes gamma-aminobutyraldehyde". Hum Genet. 93 (2): 211–2. doi:10.1007/bf00210615. PMID 8112751.
  6. ↑ Lin SW, Chen JC, Hsu LC, Hsieh CL, Yoshida A (Sep 1996). "Human gamma-aminobutyraldehyde dehydrogenase (ALDH9): cDNA sequence, genomic organization, polymorphism, chromosomal localization, and tissue expression". Genomics. 34 (3): 376–80. doi:10.1006/geno.1996.0300. PMID 8786138.
  7. 1 2 "Entrez Gene: ALDH9A1 aldehyde dehydrogenase 9 family, member A1".

Further reading

  • Kurys G, Ambroziak W, Pietruszko R (1989). "Human aldehyde dehydrogenase. Purification and characterization of a third isozyme with low Km for gamma-aminobutyraldehyde". J. Biol. Chem. 264 (8): 4715–21. PMID 2925663.
  • Kurys G, Shah PC, Kikonygo A, et al. (1994). "Human aldehyde dehydrogenase. cDNA cloning and primary structure of the enzyme that catalyzes dehydrogenation of 4-aminobutyraldehyde". Eur. J. Biochem. 218 (2): 311–20. doi:10.1111/j.1432-1033.1993.tb18379.x. PMID 8269919.
  • Kikonyogo A, Pietruszko R (1996). "Aldehyde dehydrogenase from adult human brain that dehydrogenates gamma-aminobutyraldehyde: purification, characterization, cloning and distribution". Biochem. J. 316 (1): 317–24. PMC 1217341. PMID 8645224.
  • Izaguirre G, Kikonyogo A, Pietruszko R (1998). "Tissue distribution of human aldehyde dehydrogenase E3 (ALDH9): comparison of enzyme activity with E3 protein and mRNA distribution". Comp. Biochem. Physiol. B, Biochem. Mol. Biol. 118 (1): 59–64. doi:10.1016/s0305-0491(97)00022-9. PMID 9417993.
  • Vaz FM, Fouchier SW, Ofman R, et al. (2000). "Molecular and biochemical characterization of rat gamma-trimethylaminobutyraldehyde dehydrogenase and evidence for the involvement of human aldehyde dehydrogenase 9 in carnitine biosynthesis". J. Biol. Chem. 275 (10): 7390–4. doi:10.1074/jbc.275.10.7390. PMID 10702312.
  • Izaguirre G, Pietruszko R, Cho S, MacKerell A (2002). "Human aldehyde dehydrogenase catalytic activity and structural interactions with coenzyme analogs". J. Biomol. Struct. Dyn. 19 (3): 429–47. doi:10.1080/07391102.2001.10506752. PMID 11790142.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.


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