Adrenodoxin-NADP+ reductase

Adrenodoxin-NADP+ reductase
Identifiers
EC number 1.18.1.6
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Adrenodoxin-NADP+ reductase (EC 1.18.1.6, adrenodoxin reductase, nicotinamide adenine dinucleotide phosphate-adrenodoxin reductase, ADR, NADPH:adrenal ferredoxin oxidoreductase) is an enzyme with systematic name adrendoxin:NADP+ oxidoreductase.[1][2][3][4][5][6][7] This enzyme catalyses the following chemical reaction

2 reduced adrenodoxin + NADP+ 2 oxidized adrenodoxin + NADPH + H+

Adrenodoxin-NADP+ reductase is a flavoprotein (FAD).

References

  1. ↑ Omura, T.; Sanders, E.; Estabrook, R.W.; Cooper, D.Y.; Rosenthal, O. (1966). "Isolation from adrenal cortex of a nonheme iron protein and a flavoprotein functional as a reduced triphosphopyridine nucleotide-cytochrome P-450 reductase". Arch. Biochem. Biophys. 117: 660–673. doi:10.1016/0003-9861(66)90108-1.
  2. ↑ Chu, J.W.; Kimura, T. (1973). "Studies on adrenal steroid hydroxylases. Molecular and catalytic properties of adrenodoxin reductase (a flavoprotein)". J. Biol. Chem. 248 (6): 2089–2094. PMID 4144106.
  3. ↑ Sugiyama, T.; Yamano, T. (1975). "Purification and crystallization of NADPH-adrenodoxin reductase from bovine adrenocortical mitochondria". FEBS Lett. 52 (1): 145–148. doi:10.1016/0014-5793(75)80658-2. PMID 235468.
  4. ↑ Hanukoglu, I.; Jefcoate, C.R. (1980). "Mitochondrial cytochrome P-450sec. Mechanism of electron transport by adrenodoxin". J. Biol. Chem. 255 (7): 3057–3061. PMID 6766943.
  5. ↑ Hanukoglu, I.; Hanukoglu, Z. (1986). "Stoichiometry of mitochondrial cytochromes P-450, adrenodoxin and adrenodoxin reductase in adrenal cortex and corpus luteum. Implications for membrane organization and gene regulation". Eur. J. Biochem. 157: 27–31. doi:10.1111/j.1432-1033.1986.tb09633.x. PMID 3011431.
  6. ↑ Hanukoglu, I.; Gutfinger, T. (1989). "cDNA sequence of adrenodoxin reductase. Identification of NADP-binding sites in oxidoreductases". Eur. J. Biochem. 180: 479–484. doi:10.1111/j.1432-1033.1989.tb14671.x. PMID 2924777.
  7. ↑ Ziegler, G.A.; Vonrhein, C.; Hanukoglu, I.; Schulz, G.E. (1999). "The structure of adrenodoxin reductase of mitochondrial P450 systems: electron transfer for steroid biosynthesis". J. Mol. Biol. 289: 981–990. doi:10.1006/jmbi.1999.2807. PMID 10369776.
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