Adenosylcobinamide-GDP ribazoletransferase

Adenosylcobinamide-GDP ribazoletransferase
Identifiers
EC number 2.7.8.26
CAS number 137672-85-6
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Adenosylcobinamide-GDP ribazoletransferase (EC 2.7.8.26, CobS, cobalamin synthase, cobalamin-5'-phosphate synthase, cobalamin (5'-phosphate) synthase) is an enzyme with systematic name adenosylcobinamide-GDP:alpha-ribazole ribazoletransferase.[1][2][3] This enzyme catalyses the following chemical reaction

(1) adenosylcobinamide-GDP + alpha-ribazole GMP + adenosylcobalamin
(2) adenosylcobinamide-GDP + alpha-ribazole 5'-phosphate GMP + adenosylcobalamin 5'-phosphate

References

  1. ↑ Maggio-Hall, L.A.; Escalante-Semerena, J.C. (1999). "In vitro synthesis of the nucleotide loop of cobalamin by Salmonella typhimurium enzymes". Proc. Natl. Acad. Sci. USA. 96: 11798–11803. doi:10.1073/pnas.96.21.11798. PMC 18366. PMID 10518530.
  2. ↑ Warren, M.J.; Raux, E.; Schubert, H.L.; Escalante-Semerena, J.C. (2002). "The biosynthesis of adenosylcobalamin (vitamin B12)". Nat. Prod. Rep. 19: 390–412. doi:10.1039/b108967f. PMID 12195810.
  3. ↑ Cameron, B.; Blanche, F.; Rouyez, M.C.; Bisch, D.; Famechon, A.; Couder, M.; Cauchois, L.; Thibaut, D.; Debussche, L.; Crouzet, J. (1991). "Genetic analysis, nucleotide sequence, and products of two Pseudomonas denitrificans cob genes encoding nicotinate-nucleotide: dimethylbenzimidazole phosphoribosyltransferase and cobalamin (5′-phosphate) synthase". J. Bacteriol. 173 (19): 6066–6073. PMC 208353. PMID 1917841.
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