Aculeacin-A deacylase

Aculeacin-A deacylase
Identifiers
EC number 3.5.1.70
CAS number 121479-50-3
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

In enzymology, an aculeacin-A deacylase (EC 3.5.1.70) is an enzyme that catalyzes the chemical reaction that cleaves the amide bond in aculeacin A and related neutral lipopeptide antibiotics, releasing the long-chain fatty acid side chain.

This enzyme belongs to the family of hydrolases, specifically those acting on carbon-nitrogen bonds other than peptide bonds in linear amides. The systematic name of this enzyme class is aculeacin-A amidohydrolase. This enzyme is also called aculeacin A acylase.

References

    • Takeshima H, Inokoshi J, Takada Y, Tanaka H, Omura S (April 1989). "A deacylation enzyme for aculeacin A, a neutral lipopeptide antibiotic, from Actinoplanes utahensis: purification and characterization". J. Biochem. Tokyo. 105 (4): 606&ndash, 10. PMID 2760018.


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