ARGLU1
ARGLU1 | |||||||||||||||||||||||||
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Identifiers | |||||||||||||||||||||||||
Aliases | ARGLU1, arginine and glutamate rich 1 | ||||||||||||||||||||||||
External IDs | MGI: 2442985 HomoloGene: 9960 GeneCards: ARGLU1 | ||||||||||||||||||||||||
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Orthologs | |||||||||||||||||||||||||
Species | Human | Mouse | |||||||||||||||||||||||
Entrez | |||||||||||||||||||||||||
Ensembl | |||||||||||||||||||||||||
UniProt | |||||||||||||||||||||||||
RefSeq (mRNA) | |||||||||||||||||||||||||
RefSeq (protein) | |||||||||||||||||||||||||
Location (UCSC) | Chr 13: 106.54 – 106.57 Mb | Chr 8: 8.67 – 8.69 Mb | |||||||||||||||||||||||
PubMed search | [3] | [4] | |||||||||||||||||||||||
Wikidata | |||||||||||||||||||||||||
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Arginine and glutamate-rich protein 1 is a protein that in humans is encoded by the ARGLU1 gene located at 13q33.3.[5]
The protein product of this gene has been proposed as a MED1-interacting protein required for estrogen-dependent gene transcription and breast cancer cell growth.[6]
The ARGLU1 gene expresses at least three distinct RNA splice isoforms - a fully spliced isoform coding for the protein, an isoform containing a retained intron that is detained in the nucleus, and an isoform containing an alternative exon that targets the transcript for nonsense mediated decay. Furthermore, ARGLU1 contains a long, highly evolutionarily conserved sequence known as an Ultraconserved Element (UCE) that is within the retained intron and overlaps the alternative exon. [7]
References
- 1 2 3 GRCh38: Ensembl release 89: ENSG00000134884 - Ensembl, May 2017
- 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000040459 - Ensembl, May 2017
- ↑ "Human PubMed Reference:".
- ↑ "Mouse PubMed Reference:".
- ↑ "Entrez Gene: ARGLU1 arginine and glutamate rich 1".
- ↑ Zhang D, Jiang P, Xu Q, Zhang X (May 2011). "Arginine and glutamate-rich 1 (ARGLU1) interacts with mediator subunit 1 (MED1) and is required for estrogen receptor-mediated gene transcription and breast cancer cell growth". J. Biol. Chem. 286 (20): 17746–54. doi:10.1074/jbc.M110.206029. PMC 3093850. PMID 21454576.
- ↑ "An Ultraconserved Element (UCE) controls homeostatic splicing of ARGLU1 mRNA". doi:10.1093/nar/gkw1140. PMC 5389617. PMID 27899669.
External links
- Human ARGLU1 genome location and ARGLU1 gene details page in the UCSC Genome Browser.