ANP32E

ANP32E
Available structures
PDBHuman UniProt search: PDBe RCSB
Identifiers
AliasesANP32E, LANP-L, LANPL, acidic nuclear phosphoprotein 32 family member E
External IDsHomoloGene: 137403 GeneCards: ANP32E
Gene location (Human)
Chr.Chromosome 1 (human)[1]
Band1q21.2Start150,218,417 bp[1]
End150,236,156 bp[1]
RNA expression pattern


More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

81611

n/a

Ensembl

ENSG00000143401

n/a

UniProt

Q9BTT0

n/a

RefSeq (mRNA)

NM_001136478
NM_001136479
NM_001280559
NM_001280560
NM_030920

n/a

RefSeq (protein)

NP_001129950
NP_001129951
NP_001267488
NP_001267489
NP_112182

n/a

Location (UCSC)Chr 1: 150.22 – 150.24 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

Acidic leucine-rich nuclear phosphoprotein 32 family member E is a protein that in humans is encoded by the ANP32E gene.[3][4] The ANP32E gene is located on chromosome 1q22.[3] In mammalian cells, ANP32E has been shown to be an H2A.Z chaperone capable of promoting the removal of H2A.Z from chromatin.[5] In brain tissue, ANP32E together with Cpd1 regulate protein phosphatase 2A activity at synapses during synaptogenesis[6] and has been observed to form a complex with ANP32A and SET that stabilizes short-lived mRNAs containing AU-rich elements, as well as having acetyltransferase inhibitory activity (in a complex with SET) and having a role in chromatin remodeling and transcriptional regulation.[7]

See also

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000143401 - Ensembl, May 2017
  2. ↑ "Human PubMed Reference:".
  3. 1 2 Jiang M, Ma Y, Ni X, Cao G, Ji C, Cheng H, Tang R, Xie Y, Mao Y (Nov 2002). "Molecular cloning and characterization of a novel human gene (ANP32E alias LANPL) from human fetal brain". Cytogenet Genome Res. 97 (1–2): 68–71. doi:10.1159/000064058. PMID 12438741.
  4. ↑ "Entrez Gene: ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E".
  5. ↑ Obri A, Ouararhni K, Papin C, Diebold ML, Padmanabhan K, Marek M, Stoll I, Roy L, Reilly PT, Mak TW, Dimitrov S, Romier C, Hamiche A (2014). "ANP32E is a histone chaperone that removes H2A.Z from chromatin". Nature. 505 (7485): 648–53. doi:10.1038/nature12922. PMID 24463511.
  6. ↑ Costanzo RV, Vilá-Ortíz GJ, Perandones C, Carminatti H, Matilla A, Radrizzani M (2006). "Anp32e/Cpd1 regulates protein phosphatase 2A activity at synapses during synaptogenesis". Eur. J. Neurosci. 23 (2): 309–24. doi:10.1111/j.1460-9568.2005.04555.x. PMID 16420440.
  7. ↑ Santa-Coloma TA (2003). "Anp32e (Cpd1) and related protein phosphatase 2 inhibitors". Cerebellum. 2 (4): 310–20. doi:10.1080/14734220310017212. PMID 14964690.

Further reading

  • Matilla A, Radrizzani M (2005). "The Anp32 family of proteins containing leucine-rich repeats". Cerebellum. 4 (1): 7–18. doi:10.1080/14734220410019020. PMID 15895553.
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
  • Andersen JS, Lam YW, Leung AK, Ong SE, Lyon CE, Lamond AI, Mann M (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. doi:10.1038/nature03207. PMID 15635413.
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