Alpha-1,6-mannosyl-glycoprotein 4-b-N-acetylglucosaminyltransferase

Alpha-1,6-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase
Identifiers
EC number 2.4.1.201
CAS number 119699-68-2
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Alpha-1,6-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase (EC 2.4.1.201, N-acetylglucosaminyltransferase VI, N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase VI, uridine diphosphoacetylglucosamine-glycopeptide beta-1->4-acetylglucosaminyltransferase VI, mannosyl-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, GnTVI) is an enzyme with systematic name UDP-N-acetyl-D-glucosamine:2,6-bis(N-acetyl-beta-D-glucosaminyl)-alpha-D-mannosyl-glycoprotein 4-beta-N-acetyl-D-glucosaminyltransferase.[1][2] This enzyme catalyses the following chemical reaction

UDP-N-acetyl-D-glucosamine + 2,6-bis(N-acetyl-beta-D-glucosaminyl)-alpha-D-mannosyl-R UDP + 2,4,6-tris(N-acetyl-beta-D-glucosaminyl)-alpha-D-mannosyl-R

R represents the remainder of the N-linked oligosaccharide in the glycoprotein acceptor.

References

  1. ↑ Brockhausen, I.; Hull, E.; Hindsgaul, O.; Schachter, H.; Shah, R.N.; Michnick, S.W.; Carver, J.P. (1989). "Control of glycoprotein synthesis. Detection and characterization of a novel branching enzyme from hen oviduct, UDP-N-acetylglucosamine:GlcNAc β1-6 (GlcNAc β1-2)Man α-R (GlcNAc to Man) β-4-N-acetylglucosaminyltransferase VI". J. Biol. Chem. 264 (19): 11211–11221. PMID 2525556.
  2. ↑ Taguchi, T.; Ogawa, T.; Inoue, S.; Inoue, Y.; Sakamoto, Y.; Korekane, H.; Taniguchi, N. (2000). "Purification and characterization of UDP-GlcNAc:GlcNAcβ1-6(GlcNAcβ1-2)Manα1-R [GlcNAc to Man]-β1,4-N-acetylglucosaminyltransferase VI from hen oviduct". J. Biol. Chem. 275 (42): 32598–32602. doi:10.1074/jbc.m004673200. PMID 10903319.
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