8-dimethylallylnaringenin 2'-hydroxylase

8-dimethylallylnaringenin 2'-hydroxylase
Identifiers
EC number 1.14.13.103
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

In enzymology, a 8-dimethylallylnaringenin 2'-hydroxylase (EC 1.14.13.103) is an enzyme that catalyzes the chemical reaction

sophoraflavanone B + NADPH + H+ + O2 leachianone G + NADP+ + H2O

The 4 substrates of this enzyme are sophoraflavanone B, NADPH, H+, and O2, whereas its 3 products are leachianone G, NADP+, and H2O.

This enzyme belongs to the family of oxidoreductases, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O2 with NADH or NADPH as one donor, and incorporation of one atom o oxygen into the other donor. The systematic name of this enzyme class is sophoraflavanone-B,NADPH:oxygen oxidoreductase (2'-hydroxylating). This enzyme is also called 8-DMAN 2'-hydroxylase.

References

    • Yamamoto H; Yatou A; Inoue K (2001). "8-dimethylallylnaringenin 2'-hydroxylase, the crucial cytochrome P450 mono-oxygenase for lavandulylated flavanone formation in Sophora flavescens cultured cells". Phytochemistry. 58 (5): 671&ndash, 6. doi:10.1016/S0031-9422(01)00270-9. PMID 11672730.
    • Zhao P; Inoue K; Kouno I; Yamamoto H (2003). "Characterization of leachianone G 2"-dimethylallyltransferase, a novel prenyl side-chain elongation enzyme for the formation of the lavandulyl group of sophoraflavanone G in Sophora flavescens Ait cell suspension cultures". Plant Physiol. 133 (3): 1306&ndash, 13. doi:10.1104/pp.103.025213. PMC 281625. PMID 14551337.


    This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.