7-Methylguanosine

7-Methylguanosine
Names
	IUPAC name 7-Methylguanosine
	Other names N7-Methylguanosine; 2-Amino-1,6-dihydro-7-methyl-6-oxo-9-β-D-ribofuranosylpurinium
Identifiers
CAS Number	20244-86-4 ;
3D model (JSmol)	Interactive image;
Abbreviations	m7G; m7G
ChEBI	CHEBI:20794 ;
ChemSpider	393054 ;
PubChem CID	445404;
	InChI InChI=1S/C11H15N5O5/c1-15-3-16(8-5(15)9(20)14-11(12)13-8)10-7(19)6(18)4(2-17)21-10/h3-4,6-7,10,17-19H,2H2,1H3,(H2-,12,13,14,20)/p+1/t4-,6-,7-,10-/m1/s1 Key: OGHAROSJZRTIOK-KQYNXXCUSA-O ; InChI=1/C11H15N5O5/c1-15-3-16(8-5(15)9(20)14-11(12)13-8)10-7(19)6(18)4(2-17)21-10/h3-4,6-7,10,17-19H,2H2,1H3,(H2-,12,13,14,20)/p+1/t4-,6-,7-,10-/m1/s1 Key: OGHAROSJZRTIOK-UJMNIJGGBX;
	SMILES O=C3/N=C(/N)Nc1c3n(c[n+]1[C@@H]2O[C@@H]([C@@H](O)[C@H]2O)CO)C;
Properties
Chemical formula	C11H16N5O5
Molar mass	298.28 g·mol−1
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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	Infobox references

7-Methylguanosine (m⁷G) is a modified purine nucleoside. It is a methylated version of guanosine and when found in human urine, it may be a biomarker of some types of cancer. in the RNAs, 7-Methylguanosine have been used to study and examine the reaction evolving methylguanosine. It also plays a role in mRNA as a blocking group at its 5´-end.^[1]

References

↑ Reynaud, C; Bruno, C; Boullanger, P; Grange, J; Barbesti, S; Niveleau, A (1992). "Monitoring of urinary excretion of modified nucleosides in cancer patients using a set of six monoclonal antibodies". Cancer Letters. 61 (3): 255–62. doi:10.1016/0304-3835(92)90296-8. PMID 1739950.

External links

Metabocard for 7-Methylguanosine (HMDB01107), Human Metabolome Database, University of Alberta

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[1] Reynaud, C; Bruno, C; Boullanger, P; Grange, J; Barbesti, S; Niveleau, A (1992). "Monitoring of urinary excretion of modified nucleosides in cancer patients using a set of six monoclonal antibodies". Cancer Letters. 61 (3): 255–62. doi:10.1016/0304-3835(92)90296-8. PMID 1739950.