4-hydroxybenzoate decarboxylase

4-hydroxybenzoate decarboxylase
Identifiers
EC number 4.1.1.61
CAS number 37290-53-2
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / QuickGO

In enzymology, a 4-hydroxybenzoate decarboxylase (EC 4.1.1.61) is an enzyme that catalyzes the chemical reaction

4-hydroxybenzoate phenol + CO2

Hence, this enzyme has one substrate, 4-hydroxybenzoate, and two products, phenol and CO2.

This enzyme belongs to the family of lyases, specifically the carboxy-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is 4-hydroxybenzoate carboxy-lyase (phenol-forming). Other names in common use include p-hydroxybenzoate decarboxylase, and 4-hydroxybenzoate carboxy-lyase. This enzyme participates in benzoate degradation via coa ligation.

References

    • Grant DJW; Patel JC (1969). "Non-oxidative decarboxylation of p-hydroxybenzoic acid, gentisic acid, protocatechuic acid, and gallic acid by Klebsiella aerogenes (Aerobacter aerogenes)". J. Microbiol. Serol. 35: 325&ndash, 343.
    • Tschech A; Fuchs G (1989). "Anaerobic degradation of phenol via carboxylation to 4-hydroxybenzoate - in vitro study of isotope exchange between (CO2)-C-14 and 4-hydroxybenzoate". Arch. Microbiol. 152 (6): 594&ndash, 599. doi:10.1007/BF00425493.
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