4-(2-carboxyphenyl)-2-oxobut-3-enoate aldolase
| 4-(2-carboxyphenyl)-2-oxobut-3-enoate aldolase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 4.1.2.34 | ||||||||
| CAS number | 86611-90-7 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, a 4-(2-carboxyphenyl)-2-oxobut-3-enoate aldolase (EC 4.1.2.34) is an enzyme that catalyzes the chemical reaction
- (3Z)-4-(2-carboxyphenyl)-2-oxobut-3-enoate + H2O 2-formylbenzoate + pyruvate
Thus, the two substrates of this enzyme are (3Z)-4-(2-carboxyphenyl)-2-oxobut-3-enoate and H2O, whereas its two products are 2-formylbenzoate and pyruvate.
This enzyme belongs to the family of lyases, specifically the aldehyde-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is (3Z)-4-(2-carboxyphenyl)-2-oxobut-3-enoate 2-formylbenzoate-lyase (pyruvate-forming). Other names in common use include 2'-carboxybenzalpyruvate aldolase, (3E)-4-(2-carboxyphenyl)-2-oxobut-3-enoate, 2-carboxybenzaldehyde-lyase, and (3Z)-4-(2-carboxyphenyl)-2-oxobut-3-enoate 2-formylbenzoate-lyase. This enzyme participates in naphthalene and anthracene degradation.
References
- Barnsley EA (1983). "Phthalate pathway of phenanthrene metabolism: formation of 2'-carboxybenzalpyruvate". J. Bacteriol. 154 (1): 113&ndash, 7. PMC 217437. PMID 6833175.