4,4'-Diapophytoene desaturase

4,4'-diapophytoene desaturase
Identifiers
EC number 1.3.8.2
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

4,4'-Diapophytoene desaturase (EC 1.3.8.2, dehydrosqualene desaturase, CrtN, 4,4'-diapophytoene:FAD oxidoreductase) is an enzyme with systematic name 15-cis-4,4'-diapophytoene:FAD oxidoreductase.[1][2][3] This enzyme catalyses the following chemical reaction

15-cis-4,4'-diapophytoene + 4 FAD all-trans-4,4'-diapolycopene + 4 FADH2 (overall reaction)
(1a) 15-cis-4,4'-diapophytoene + FAD all-trans-4,4'-diapophytofluene + FADH2
(1b) all-trans-4,4'-diapophytofluene + FAD all-trans-4,4'-diapo-zeta-carotene + FADH2
(1c) all-trans-4,4'-diapo-zeta-carotene + FAD all-trans-4,4'-diaponeurosporene + FADH2
(1d) all-trans-4,4'-diaponeurosporene + FAD all-trans-4,4'-diapolycopene + FADH2

This enzyme is typical of Staphylococcus aureus and some other bacteria such as Heliobacillus sp.

References

  1. ↑ Wieland, B.; Feil, C.; Gloria-Maercker, E.; Thumm, G.; Lechner, M.; Bravo, J.M.; Poralla, K.; Gotz, F. (1994). "Genetic and biochemical analyses of the biosynthesis of the yellow carotenoid 4,4′-diaponeurosporene of Staphylococcus aureus". J. Bacteriol. 176 (24): 7719–7726. PMC 197231. PMID 8002598.
  2. ↑ Raisig, A.; Sandmann, G. (1999). "4,4′-diapophytoene desaturase: catalytic properties of an enzyme from the C30 carotenoid pathway of Staphylococcus aureus". J. Bacteriol. 181 (19): 6184–6187. PMC 103650. PMID 10498735.
  3. ↑ Raisig, A.; Sandmann, G. (2001). "Functional properties of diapophytoene and related desaturases of C30 to C40 carotenoid biosynthetic pathways". Biochim. Biophys. Acta. 1533 (2): 164–170. doi:10.1016/s1388-1981(01)00154-8. PMID 11566453.
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