3,4-Dehydroadipyl-CoA semialdehyde dehydrogenase (NADP+)

3,4-Dehydroadipyl-CoA semialdehyde dehydrogenase (NADP+)
Identifiers
EC number 1.2.1.77
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

3,4-Dehydroadipyl-CoA semialdehyde dehydrogenase (NADP+) (EC 1.2.1.77, BoxD, 3,4-dehydroadipyl-CoA semialdehyde dehydrogenase) is an enzyme with systematic name 3,4-didehydroadipyl-CoA semialdehyde:NADP+ oxidoreductase.[1][2] This enzyme catalyses the following chemical reaction

3,4-didehydroadipyl-CoA semialdehyde + NADP+ + H2O 3,4-didehydroadipyl-CoA + NADPH + H+

This enzyme catalyses a step in the aerobic benzoyl-coenzyme A catabolic pathway in Azoarcus evansii and Burkholderia xenovorans.

References

  1. ↑ Gescher, J.; Ismail, W.; Olgeschlager, E.; Eisenreich, W.; Worth, J.; Fuchs, G. (2006). "Aerobic benzoyl-coenzyme A (CoA) catabolic pathway in Azoarcus evansii: conversion of ring cleavage product by 3,4-dehydroadipyl-CoA semialdehyde dehydrogenase". J. Bacteriol. 188 (8): 2919–2927. doi:10.1128/JB.188.8.2919-2927.2006. PMC 1446997. PMID 16585753.
  2. ↑ Bains, J.; Boulanger, M.J. (2008). "Structural and biochemical characterization of a novel aldehyde dehydrogenase encoded by the benzoate oxidation pathway in Burkholderia xenovorans LB400". J. Mol. Biol. 379 (3): 597–608. doi:10.1016/j.jmb.2008.04.031. PMID 18462753.
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