23S rRNA pseudouridine955/2504/2580 synthase

23S rRNA pseudouridine955/2504/2580 synthase
Identifiers
EC number 5.4.99.24
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

23S rRNA pseudouridine955/2504/2580 synthase (EC 5.4.99.24, RluC, pseudouridine synthase RluC) is an enzyme with systematic name 23S rRNA-uridine955/2504/2580 uracil mutase.[1][2][3][4] This enzyme catalyses the following chemical reaction

23S rRNA uridine955/uridine2504/uridine2580 23S rRNA pseudouridine955/pseudouridine2504/pseudouridine2580

The enzyme converts uridines at position 955, 2504 and 2580 of 23S rRNA to pseudouridines.

References

  1. ↑ Jiang, M.; Sullivan, S.M.; Walker, A.K.; Strahler, J.R.; Andrews, P.C.; Maddock, J.R. (2007). "Identification of novel Escherichia coli ribosome-associated proteins using isobaric tags and multidimensional protein identification techniques". J. Bacteriol. 189: 3434–3444. doi:10.1128/jb.00090-07. PMC 1855874. PMID 17337586.
  2. ↑ Conrad, J.; Sun, D.; Englund, N.; Ofengand, J. (1998). "The rluC gene of Escherichia coli codes for a pseudouridine synthase that is solely responsible for synthesis of pseudouridine at positions 955, 2504, and 2580 in 23 S ribosomal RNA". J. Biol. Chem. 273: 18562–18566. doi:10.1074/jbc.273.29.18562. PMID 9660827.
  3. ↑ Corollo, D.; Blair-Johnson, M.; Conrad, J.; Fiedler, T.; Sun, D.; Wang, L.; Ofengand, J.; Fenna, R. (1999). "Crystallization and characterization of a fragment of pseudouridine synthase RluC from Escherichia coli". Acta Crystallogr. D. 55: 302–304. doi:10.1107/s090744499801021x. PMID 10089432.
  4. ↑ Toh, S.M.; Mankin, A.S. (2008). "An indigenous posttranscriptional modification in the ribosomal peptidyl transferase center confers resistance to an array of protein synthesis inhibitors". J. Mol. Biol. 380: 593–597. doi:10.1016/j.jmb.2008.05.027. PMC 5367387. PMID 18554609.
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