2-phospho-L-lactate transferase

2-phospho-L-lactate transferase
Identifiers
EC number 2.7.8.28
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

2-phospho-L-lactate transferase (EC 2.7.8.28, LPPG:Fo 2-phospho-L-lactate transferase, LPPG:7,8-didemethyl-8-hydroxy-5-deazariboflavin 2-phospho-L-lactate transferase, MJ1256, lactyl-2-diphospho-(5')guanosine:Fo 2-phospho-L-lactate transferase, CofD) is an enzyme with systematic name (2S)-lactyl-2-diphospho-5'-guanosine:7,8-didemethyl-8-hydroxy-5-deazariboflavin 2-phospho-L-lactate transferase.[1][2] This enzyme catalyses the following chemical reaction

(2S)-lactyl-2-diphospho-5'-guanosine + 7,8-didemethyl-8-hydroxy-5-deazariboflavin GMP + coenzyme F420-0

This enzyme is involved in the biosynthesis of coenzyme F420.

References

  1. ↑ Graupner, M.; Xu, H.; White, R.H. (2002). "Characterization of the 2-phospho-L-lactate transferase enzyme involved in coenzyme F420 biosynthesis in Methanococcus jannaschii". Biochemistry. 41: 3754–3761. doi:10.1021/bi011937v. PMID 11888293.
  2. ↑ Forouhar, F.; Abashidze, M.; Xu, H.; Grochowski, L.L.; Seetharaman, J.; Hussain, M.; Kuzin, A.; Chen, Y.; Zhou, W.; Xiao, R.; Acton, T.B.; Montelione, G.T.; Galinier, A.; White, R.H.; Tong, L. (2008). "Molecular insights into the biosynthesis of the F420 coenzyme". J. Biol. Chem. 283: 11832–11840. doi:10.1074/jbc.m710352200. PMC 2431047. PMID 18252724.
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