2-hydroxychromene-2-carboxylate isomerase

2-hydroxychromene-2-carboxylate isomerase
Identifiers
EC number 5.99.1.4
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

2-hydroxychromene-2-carboxylate isomerase (EC 5.99.1.4, HCCA isomerase, 2HC2CA isomerase, 2-hydroxychromene-2-carboxylic acid isomerase) is an enzyme with systematic name 2-hydroxy-2H-chromene-2-carboxylate---(3E)-4-(2-hydroxyphenyl)-2-oxobut-3-enoate isomerase.[1][2][3][4] This enzyme catalyses the following chemical reaction

2-hydroxy-2H-chromene-2-carboxylate (3E)-4-(2-hydroxyphenyl)-2-oxobut-3-enoate

This enzyme is involved in naphthalene degradation.

References

  1. ↑ Ohmoto, T.; Kinoshita, T.; Moriyoshi, K.; Sakai, K.; Hamada, N.; Ohe, T. (1998). "Purification and some properties of 2-hydroxychromene-2-carboxylate isomerase from naphthalenesulfonate-assimilating Pseudomonas sp. TA-2". J. Biochem. 124 (3): 591–597. doi:10.1093/oxfordjournals.jbchem.a022152. PMID 9722670.
  2. ↑ Keck, A.; Conradt, D.; Mahler, A.; Stolz, A.; Mattes, R.; Klein, J. (2006). "Identification and functional analysis of the genes for naphthalenesulfonate catabolism by Sphingomonas xenophaga BN6". Microbiology. 152: 1929–1940. doi:10.1099/mic.0.28783-0. PMID 16804169.
  3. ↑ Eaton, R.W. (1994). "Organization and evolution of naphthalene catabolic pathways: sequence of the DNA encoding 2-hydroxychromene-2-carboxylate isomerase and trans-o-hydroxybenzylidenepyruvate hydratase-aldolase from the NAH7 plasmid". J. Bacteriol. 176 (24): 7757–7762. doi:10.1128/jb.176.24.7757-7762.1994. PMC 197239. PMID 8002605.
  4. ↑ Thompson, L.C.; Ladner, J.E.; Codreanu, S.G.; Harp, J.; Gilliland, G.L.; Armstrong, R.N. (2007). "2-Hydroxychromene-2-carboxylic acid isomerase: a kappa class glutathione transferase from Pseudomonas putida". Biochemistry. 46 (23): 6710–6722. doi:10.1021/bi700356u. PMID 17508726.
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