hamartin

English

Noun

hamartin (uncountable)

  1. (biochemistry) A peripheral membrane protein encoded in humans by the TSC1 gene, and implicated as a tumor suppressor.
    • 2015 July 14, “Lymphangioleiomyomatosis Biomarkers Linked to Lung Metastatic Potential and Cell Stemness”, in PLOS ONE‎, DOI:10.1371/journal.pone.0132546:
      Notably, in breast cancer, relative low expression of hamartin and tuberin (TSC1 and TSC2 products, respectively) is associated with poor clinical outcome, and depletion of tuberin promotes metastasis.
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