Pseudoporfyrie

	Pseudoporfyrie
	Coderingen
eMedicine	derm/358
Portaal	Geneeskunde

Pseudoporfyrie is een huidaandoening met de kenmerken van de stofwisselingsziekte porphyria cutanea tarda, echter zonder de bijbehorende verstoring van het porfyrine-profiel. De ziekte wordt dan ook niet (zoals porfyrie) veroorzaakt door enzymdefecten, maar door sommige medicijnen, UV-blootstelling of nierdialyse. Ook is een associatie gemeld met het gebruik van cola.

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Klachten

De klachten van de huid zijn beperkt tot gebieden die aan zonlicht zijn blootgesteld. De huid is fragiel, er ontstaan blaren die met littekens en milien genezen. Hypertrichose komt voor. Ook bij histologisch onderzoek zijn de tekenen van porfyrie te zien.

Uitlokkende factoren

Een niet-volledige lijst met factoren, waarvan beweerd wordt dat ze pseudo-porfyrie veroorzaakten.

Factor	Bron
Nierdialyse	[1]
Zonnebank en Lichttherapie	[2][3]
NSAIDs Rofecoxib Nabumeton Naproxen	[4] [5] [6] [7]
Anticonceptiepil	[8]
Antibiotica	[9][10]
Furosemide / Hydrochloorthiazide	[11]
Ciclosporine	[12]
Amiodaron	[13]
Isotretinoïne	[14]
Fluorouracil	[15]
Cola	[16]

Zie ook

Bronnen, noten en/of referenties

Cooke NS, McKenna K. A case of haemodialysis-associated pseudoporphyria successfully treated with oral N-acetylcysteine. Clin Exp Dermatol. 2007 Jan;32(1):64-6. | In pubmed
Oh C, Jones B, Solomon R, Egan CA. Pseudoporphyria secondary to narrowband UVB phototherapy for psoriasis. Australas J Dermatol. 2006 May;47(2):134-6. | In pubmed
Wilson CL, Mendelsohn SS. Identical twins with sunbed-induced pseudoporphyria. J R Soc Med. 1992 Jan;85(1):45-6. | In pubmed
Bryant P, Lachman P. Pseudoporphyria secondary to non-steroidal anti-inflammatory drugs. Arch Dis Child. 2003 Nov;88(11):961. | In pubmed
Markus R, Reddick ME, Rubenstein MC. Rofecoxib-induced pseudoporphyria. J Am Acad Dermatol. 2004 Apr;50(4):647-8. | In pubmed
Antony F, Layton AM. Nabumetone-associated pseudoporphyria. Br J Dermatol. 2000 May;142(5):1067-9. | In pubmed
Maerker JM, Harm A, Foeldvari I, Hoger PH. 'Naproxen-induced pseudoporphyria' Hautarzt. 2001 Nov;52(11):1026-9. | In pubmed
Silver EA, Silver AH, Silver DS, McCalmont TH. Pseudoporphyria induced by oral contraceptive pills. Arch Dermatol. 2003 Feb;139(2):227-8. | In pubmed
Phung TL, Pipkin CA, Tahan SR, Chiu DS. Beta-lactam antibiotic-induced pseudoporphyria. J Am Acad Dermatol. 2004 Aug;51(2 Suppl):S80-2. | In pubmed
Tolland JP, McKeown PP, Corbett JR. Voriconazole-induced pseudoporphyria. Photodermatol Photoimmunol Photomed. 2007 Feb;23(1):29-31. | In pubmed
Pseudoporphyria: eMedicine Dermatology
Hivnor C, Nosauri C, James W, Poh-Fitzpatrick M. Cyclosporine-induced pseudoporphyria. Arch Dermatol. 2003 Oct;139(10):1373-4. | In pubmed
Parodi A, Guarrera M, Rebora A. Amiodarone-induced pseudoporphyria. Photodermatol. 1988 Jun;5(3):146-7. | In pubmed
Riordan CA, Anstey A, Wojnarowska F. Isotretinoin-associated pseudoporphyria. Clin Exp Dermatol. 1993 Jan;18(1):69-71. | In pubmed
Laidman PJ, Gebauer K, Trotter J. 5-Fluorouracil-induced pseudoporphyria. Aust N Z J Med. 1992 Aug;22(4):385. | In pubmed
Judd L. Pseudoporphyria due to cola. Int J Dermatol. 1991 Sep;30(9):674-5. | In pubmed

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[1] Cooke NS, McKenna K. A case of haemodialysis-associated pseudoporphyria successfully treated with oral N-acetylcysteine. Clin Exp Dermatol. 2007 Jan;32(1):64-6. | In pubmed

[2] Oh C, Jones B, Solomon R, Egan CA. Pseudoporphyria secondary to narrowband UVB phototherapy for psoriasis. Australas J Dermatol. 2006 May;47(2):134-6. | In pubmed

[3] Wilson CL, Mendelsohn SS. Identical twins with sunbed-induced pseudoporphyria. J R Soc Med. 1992 Jan;85(1):45-6. | In pubmed

[4] Bryant P, Lachman P. Pseudoporphyria secondary to non-steroidal anti-inflammatory drugs. Arch Dis Child. 2003 Nov;88(11):961. | In pubmed

[5] Markus R, Reddick ME, Rubenstein MC. Rofecoxib-induced pseudoporphyria. J Am Acad Dermatol. 2004 Apr;50(4):647-8. | In pubmed

[6] Antony F, Layton AM. Nabumetone-associated pseudoporphyria. Br J Dermatol. 2000 May;142(5):1067-9. | In pubmed

[7] Maerker JM, Harm A, Foeldvari I, Hoger PH. 'Naproxen-induced pseudoporphyria' Hautarzt. 2001 Nov;52(11):1026-9. | In pubmed

[8] Silver EA, Silver AH, Silver DS, McCalmont TH. Pseudoporphyria induced by oral contraceptive pills. Arch Dermatol. 2003 Feb;139(2):227-8. | In pubmed

[9] Phung TL, Pipkin CA, Tahan SR, Chiu DS. Beta-lactam antibiotic-induced pseudoporphyria. J Am Acad Dermatol. 2004 Aug;51(2 Suppl):S80-2. | In pubmed

[10] Tolland JP, McKeown PP, Corbett JR. Voriconazole-induced pseudoporphyria. Photodermatol Photoimmunol Photomed. 2007 Feb;23(1):29-31. | In pubmed

[11] Pseudoporphyria: eMedicine Dermatology

[12] Hivnor C, Nosauri C, James W, Poh-Fitzpatrick M. Cyclosporine-induced pseudoporphyria. Arch Dermatol. 2003 Oct;139(10):1373-4. | In pubmed

[13] Parodi A, Guarrera M, Rebora A. Amiodarone-induced pseudoporphyria. Photodermatol. 1988 Jun;5(3):146-7. | In pubmed

[14] Riordan CA, Anstey A, Wojnarowska F. Isotretinoin-associated pseudoporphyria. Clin Exp Dermatol. 1993 Jan;18(1):69-71. | In pubmed

[15] Laidman PJ, Gebauer K, Trotter J. 5-Fluorouracil-induced pseudoporphyria. Aust N Z J Med. 1992 Aug;22(4):385. | In pubmed

[16] Judd L. Pseudoporphyria due to cola. Int J Dermatol. 1991 Sep;30(9):674-5. | In pubmed