Z12 small nucleolar RNA

Z12 small nucleolar RNA is a non-coding RNA (ncRNA) molecule which functions in the modification of other small nuclear RNAs (snRNAs). This type of modifying RNA is usually located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis.[1] It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA. Z12 snoRNA belongs to the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs.[1]

Small nucleolar RNA SNORD104
Predicted secondary structure and sequence conservation of SNORND104
Identifiers
SymbolSNORND104
Alt. SymbolssnoZ12; Z12
RfamRF00289
Other data
RNA typeGene; snRNA; snoRNA; CD-box
Domain(s)Eukaryota
GO0006396 0005730
SO0001263
LocusChr. 13
PDB structuresPDBe

References

  1. Galardi S, Fatica A, Bachi A, Scaloni A, Presutti C, Bozzoni I (October 2002). "Purified box C/D snoRNPs are able to reproduce site-specific 2'-O-methylation of target RNA in vitro". Molecular and Cellular Biology. 22 (19): 6663–8. doi:10.1128/MCB.22.19.6663-6668.2002. PMC 134041. PMID 12215523.
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